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Tbio
SMAD1
Mothers against decapentaplegic homolog 1

Protein Summary
Description
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302085
  • ENSP00000305769
  • ENSG00000170365
  • ENST00000394092
  • ENSP00000377652
  • ENST00000515385
  • ENSP00000426568

Symbol
  • BSP1
  • MADH1
  • MADR1
  • BSP1
  • JV41
  • BSP-1
  • JV4-1
  • MADH1
  • MADR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
molecular function
0.99
biological process
0.98
phosphatase
0.98
virus perturbation
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.71   (req: < 5)
Gene RIFs: 104   (req: <= 3)
Antibodies: 1217   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.71   (req: >= 5)
Gene RIFs: 104   (req: > 3)
Antibodies: 1217   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 43
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
2
2
64
red blood cell distribution width
2
1
2
45.6
high density lipoprotein cholesterol measurement
1
1
1
25.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
64
red blood cell distribution width
2
45.6
high density lipoprotein cholesterol measurement
1
25.7
Protein Data Bank (10)
1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (59)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Deubiquitination
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism of proteins
Post-translational protein modification
Gene Ontology Terms (53)
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (137)
1 – 10 of 137
SMURF2
Tbio
Family: Enzyme
Novelty: 0.00920984
p_int: 0.999999089
p_ni: 9.1e-7
Score: 0.984
Data Source: BioPlex,STRINGDB
GP9
Tbio
Novelty: 0.00365769
p_int: 0.999325995
p_ni: 0.000125204
p_wrong: 0.000548801
Data Source: BioPlex
SMAD4
Tbio
Family: TF
Novelty: 0.00047069
Score: 0.984
Data Source: Reactome,STRINGDB
SKI
Tbio
Novelty: 0.02109924
Score: 0.983
Data Source: Reactome,STRINGDB
BMPR1A
Tchem
Family: Kinase
Novelty: 0.00343928
Score: 0.982
Data Source: Reactome,STRINGDB
SMURF1
Tchem
Family: Enzyme
Novelty: 0.00754708
Score: 0.978
Data Source: STRINGDB
ACVR1
Tchem
Family: Kinase
Novelty: 0.00284646
Score: 0.977
Data Source: STRINGDB
TGFBR1
Tchem
Family: Kinase
Novelty: 0.00081645
Score: 0.975
Data Source: STRINGDB
BMP2
Tbio
Novelty: 0.00016974
Score: 0.975
Data Source: Reactome,STRINGDB
BMP4
Tchem
Novelty: 0.00047387
Score: 0.974
Data Source: STRINGDB
Publication Statistics
PubMed Score  31.71

PubMed score by year
PubTator Score  342.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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