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Tbio
SMAD2
Mothers against decapentaplegic homolog 2

Protein Summary
Description
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell pro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262160
  • ENSP00000262160
  • ENSG00000175387
  • ENST00000356825
  • ENSP00000349282
  • ENST00000402690
  • ENSP00000384449
  • ENST00000586040
  • ENSP00000466193

Symbol
  • MADH2
  • MADR2
  • JV18
  • MADH2
  • MADR2
  • JV18-1
  • hMAD-2
  • hSMAD2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
molecular function
1
virus perturbation
1
biological term
0.99


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2650.17   (req: < 5)
Gene RIFs: 287   (req: <= 3)
Antibodies: 1763   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2650.17   (req: >= 5)
Gene RIFs: 287   (req: > 3)
Antibodies: 1763   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 69
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0