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Tbio
SMAD2
Mothers against decapentaplegic homolog 2

Protein Summary
Description
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell pro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262160
  • ENSP00000262160
  • ENSG00000175387
  • ENST00000356825
  • ENSP00000349282
  • ENST00000402690
  • ENSP00000384449
  • ENST00000586040
  • ENSP00000466193

Symbol
  • MADH2
  • MADR2
  • JV18
  • MADH2
  • MADR2
  • JV18-1
  • hMAD-2
  • hSMAD2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
molecular function
1
virus perturbation
1
biological term
0.99


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2293.68   (req: < 5)
Gene RIFs: 287   (req: <= 3)
Antibodies: 1763   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2293.68   (req: >= 5)
Gene RIFs: 287   (req: > 3)
Antibodies: 1763   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 69
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
SMAD family member 2
697581
Mouse
MGI:108051
17126
Rat
RGD:3031
29357
Dog
SMAD family member 2
VGNC:46519
480144
Horse
SMAD family member 2
VGNC:23311
100033843
Species
Name
OMA
EggNOG
Inparanoid
Macaque
SMAD family member 2
Mouse
Rat
Dog
SMAD family member 2
Horse
SMAD family member 2
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15796-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (89)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Developmental Biology
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Name
Explore in Pharos
Explore in Source
Deubiquitination
Developmental Biology
Disease
Diseases of signal transduction
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Gene Ontology Terms (79)
Items per page:
10
1 – 10 of 25
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Protein-Protein Interactions (469)
1 – 10 of 469
SMAD3
Tbio
Family: TF
Novelty: 0.00048058
p_int: 1
p_wrong: 1e-9
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
ZFYVE9
Tbio
Novelty: 0.00565862
p_int: 0.999999952
p_ni: 4.5e-8
p_wrong: 2e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
SKIL
Tbio
Novelty: 0.00788464
p_int: 0.999999934
p_ni: 5.6e-8
p_wrong: 1.1e-8
Score: 0.991
Data Source: BioPlex,Reactome,STRINGDB
SMAD9
Tbio
Family: TF
Novelty: 0.00285887
p_int: 0.99999992
p_ni: 1e-9
p_wrong: 8e-8
Score: 0.749
Data Source: BioPlex,STRINGDB
SKI
Tbio
Novelty: 0.02109924
p_int: 0.99999954
p_ni: 4.59e-7
p_wrong: 1e-9
Score: 0.987
Data Source: BioPlex,Reactome,STRINGDB
LDLRAD4
Tbio
Novelty: 0.04881486
p_int: 0.99999565
p_ni: 0.000001944
p_wrong: 0.000002405
Score: 0.763
Data Source: BioPlex,STRINGDB
HINT3
Tdark
Novelty: 1.14285714
p_int: 0.99995507
p_ni: 0.000044929
p_wrong: 1e-9
Data Source: BioPlex
LEMD3
Tbio
Novelty: 0.00579701
p_int: 0.999925484
p_ni: 0.000074515
Score: 0.792
Data Source: BioPlex,STRINGDB
SMAD4
Tbio
Family: TF
Novelty: 0.00047069
p_int: 0.999703251
p_ni: 0.00005911
p_wrong: 0.00023764
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
BTBD9
Tbio
Novelty: 0.02793632
p_int: 0.904085093
p_ni: 0.095678132
p_wrong: 0.000236775
Data Source: BioPlex
Publication Statistics
PubMed Score  2293.68

PubMed score by year
PubTator Score  1048.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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