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Tchem
NCOA1
Nuclear receptor coactivator 1

Protein Summary
Description
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. The protein enc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000288599
  • ENSP00000288599
  • ENSG00000084676
  • ENST00000348332
  • ENSP00000320940
  • ENST00000395856
  • ENSP00000379197
  • ENST00000405141
  • ENSP00000385097
  • ENST00000406961
  • ENSP00000385216

Symbol
  • BHLHE74
  • SRC1
  • SRC1
  • KAT13A
  • RIP160
  • F-SRC-1
  • bHLHe42
  • bHLHe74
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
molecular function
1
protein domain
1
disease perturbation
0.99
kinase perturbation
0.99


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.6   (req: < 5)
Gene RIFs: 75   (req: <= 3)
Antibodies: 388   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.6   (req: >= 5)
Gene RIFs: 75   (req: > 3)
Antibodies: 388   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL1808264
chemical structure image
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
2
2
75.6
body mass index
1
1
1
74.9
1
1
0
1.1
37.3
grip strength measurement
1
1
1
18.5
BMI-adjusted waist circumference
1
1
1
10
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
75.6
body mass index
1
74.9
0
1.1
37.3
grip strength measurement
1
18.5
BMI-adjusted waist circumference
1
10
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor coactivator 1
VGNC:310
459068
Macaque
nuclear receptor coactivator 1
718524
Mouse
MGI:1276523
17977
Rat
RGD:1309046
313929
Dog
nuclear receptor coactivator 1
VGNC:43659
475684
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor coactivator 1
Macaque
nuclear receptor coactivator 1
Mouse
Rat
Dog
nuclear receptor coactivator 1
Protein Structure (199 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15788-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 199
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (76)
Activation of gene expression by SREBF (SREBP) (R-HSA-2426168)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of gene expression by SREBF (SREBP)
Reactome
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Reactome
Bile acid and bile salt metabolism
Reactome
Biological oxidations
Reactome
Chromatin modifying enzymes
Name
Explore in Pharos
Explore in Source
Activation of gene expression by SREBF (SREBP)
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Bile acid and bile salt metabolism
Biological oxidations
Chromatin modifying enzymes
Gene Ontology Terms (35)
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (269)
1 – 10 of 269
RABGGTB
Tbio
Family: Enzyme
Novelty: 0.06786314
p_int: 0.999998645
p_ni: 0.000001354
p_wrong: 1e-9
Data Source: BioPlex
FAM131B
Tdark
Novelty: 0.3424123
p_int: 0.999983793
p_ni: 0.000016202
p_wrong: 5e-9
Score: 0.208
Data Source: BioPlex,STRINGDB
NR1I3
Tchem
Family: NR
Novelty: 0.00221694
p_int: 0.999972998
p_ni: 0.000026824
p_wrong: 1.78e-7
Score: 0.905
Data Source: BioPlex,STRINGDB
HDAC6
Tclin
Family: Epigenetic
Novelty: 0.00122232
p_int: 0.999946969
p_ni: 0.000052888
p_wrong: 1.43e-7
Score: 0.21
Data Source: BioPlex,STRINGDB
C19orf57
Tdark
Novelty: 1.59437078
p_int: 0.999938025
p_ni: 0.000061947
p_wrong: 2.9e-8
Score: 0.29
Data Source: BioPlex,STRINGDB
PLA2G10
Tchem
Family: Enzyme
Novelty: 0.00289317
p_int: 0.999908985
p_ni: 0.000091002
p_wrong: 1.2e-8
Data Source: BioPlex
TRPC4AP
Tbio
Novelty: 0.02170224
p_int: 0.999589143
p_ni: 0.000385495
p_wrong: 0.000025362
Score: 0.195
Data Source: BioPlex,STRINGDB
SNRPC
Tbio
Novelty: 0.02049921
p_int: 0.998604326
p_ni: 0.001386505
p_wrong: 0.000009169
Score: 0.284
Data Source: BioPlex,STRINGDB
SLX1A
Tbio
Family: Enzyme
Novelty: 0.0310173
p_int: 0.997457677
p_ni: 0.001031893
p_wrong: 0.00151043
Data Source: BioPlex
GPSM3
Tbio
Novelty: 0.01632501
p_int: 0.959712281
p_ni: 0.033074772
p_wrong: 0.007212947
Data Source: BioPlex
Publication Statistics
PubMed Score  284.60

PubMed score by year
PubTator Score  185.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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