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Tbio
TOMM34
Mitochondrial import receptor subunit TOM34

Protein Summary
Description
Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state. The protein encoded by this gene is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane, has a weak ATPase activity and contains 6 TPR repeats. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372813
  • ENSP00000361900
  • ENSG00000025772

Symbol
  • URCC3
  • TOM34
  • URCC3
  • HTOM34P
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
interacting protein
0.85
kinase perturbation
0.81
virus perturbation
0.79
transcription factor perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.79   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 263   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.79   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 263   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
4
4
96.1
basophil count
1
1
1
74.3
basophil percentage of leukocytes
1
1
1
74.2
chronotype measurement
2
1
1
1
63.7
blood protein measurement
1
1
1
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
96.1
basophil count
1
74.3
basophil percentage of leukocytes
1
74.2
chronotype measurement
1
1
63.7
blood protein measurement
1
47.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
translocase of outer mitochondrial membrane 34
VGNC:6285
458274
Mouse
MGI:1914395
67145
Rat
RGD:1309029
311621
Dog
translocase of outer mitochondrial membrane 34
VGNC:49628
477239
Horse
translocase of outer mitochondrial membrane 34
VGNC:50511
100070847
Species
Name
OMA
EggNOG
Inparanoid
Chimp
translocase of outer mitochondrial membrane 34
Mouse
Rat
Dog
translocase of outer mitochondrial membrane 34
Horse
translocase of outer mitochondrial membrane 34
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q15785-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (63)
1 – 10 of 63
GTF2E2
Tbio
Novelty:  0.18033153
p_int:  0.99328349
p_ni:  0.00671651
Score:  0.166
Data Source:  BioPlex,STRINGDB
COL10A1
Tbio
Novelty:  0.00521991
p_int:  0.990880095
p_ni:  0.009119905
Score:  0.188
Data Source:  BioPlex,STRINGDB
AKIRIN2
Tbio
Novelty:  0.04603317
p_int:  0.983826513
p_ni:  0.016173486
Score:  0.177
Data Source:  BioPlex,STRINGDB
FAM24B
Tdark
Novelty:  1.04675689
p_int:  0.981351094
p_ni:  0.005061623
p_wrong:  0.013587283
Data Source:  BioPlex
USP47
Tchem
Family:  Enzyme
Novelty:  0.07579226
p_int:  0.969251881
p_ni:  0.030748119
Data Source:  BioPlex
CCDC82
Tdark
Novelty:  0.48211191
p_int:  0.947692066
p_ni:  0.052307915
p_wrong:  1.9e-8
Score:  0.19
Data Source:  BioPlex,STRINGDB
FUOM
Tbio
Family:  Enzyme
Novelty:  0.0562349
p_int:  0.936024685
p_ni:  0.06397528
p_wrong:  3.6e-8
Score:  0.177
Data Source:  BioPlex,STRINGDB
GPR21
Tdark
Family:  GPCR
Novelty:  0.90865557
p_int:  0.930059762
p_ni:  0.06994
p_wrong:  2.39e-7
Data Source:  BioPlex
SLC16A11
Tbio
Family:  Transporter
Novelty:  0.07860306
p_int:  0.908291635
p_ni:  0.091014434
p_wrong:  0.000693931
Score:  0.219
Data Source:  BioPlex,STRINGDB
ZNF490
Tdark
Family:  TF
Novelty:  2.7619637
p_int:  0.906485048
p_ni:  0.093216765
p_wrong:  0.000298187
Score:  0.206
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  19.79

PubMed score by year
PubTator Score  14.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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