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Tbio
NEUROD2
Neurogenic differentiation factor 2

Protein Summary
Description
Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter (By similarity). This gene encodes a member of the neuroD family of neuro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302584
  • ENSP00000306754
  • ENSG00000171532

Symbol
  • BHLHA1
  • NDRF
  • NDRF
  • bHLHa1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.95
molecular function
0.84
disease perturbation
0.68
transcription factor
0.63
PubMedID
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.44   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.44   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
23.3
smoking initiation
1
1
1
13.5
refractive error measurement
1
1
1
6.8
erythrocyte count
1
1
1
4.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
23.3
smoking initiation
1
13.5
refractive error measurement
1
6.8
erythrocyte count
1
4.6
Gene Ontology Terms (22)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (34)
1 – 10 of 34
CPLX2
Tbio
Novelty: 0.01821493
Score: 0.826
Data Source: STRINGDB
CDC20
Tbio
Novelty: 0.00197887
Score: 0.82
Data Source: STRINGDB
MYT1L
Tbio
Family: TF
Novelty: 0.0174369
Score: 0.758
Data Source: STRINGDB
ANAPC1
Tbio
Family: Enzyme
Novelty: 0.0521845
Score: 0.718
Data Source: STRINGDB
TCF4
Tbio
Family: TF
Novelty: 0.0019718
Score: 0.696
Data Source: STRINGDB
ASCL1
Tbio
Family: TF
Novelty: 0.00274239
Score: 0.682
Data Source: STRINGDB
TBR1
Tbio
Family: TF
Novelty: 0.00676736
Score: 0.648
Data Source: STRINGDB
CKS1B
Tbio
Family: Enzyme
Novelty: 0.00766779
Score: 0.575
Data Source: STRINGDB
POU3F2
Tbio
Family: TF
Novelty: 0.00649458
Score: 0.556
Data Source: STRINGDB
PGAP3
Tbio
Novelty: 0.01842385
Score: 0.535
Data Source: STRINGDB
Publication Statistics
PubMed Score  56.44

PubMed score by year
PubTator Score  17.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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