Tbio CHI3L2 Chitinase-3-like protein 2

Protein Summary

Description

Lectin that binds chitooligosaccharides and other glycans with high affinity, but not heparin. Has no chitinase activity. The protein encoded by this gene is similar to bacterial chitinases but lacks chitinase activity. The encoded protein is secreted and is involved in cartilage biogenesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Uniprot Accession IDs

• Q15782
• A6NNY3
• B4DPR7
• Q15749
• Q15783
• Q5VUV7
• Q96F97

Gene Name

• CHI3L2

Ensembl ID

• ENST00000369744
• ENSP00000358759
• ENSG00000064886
• ENST00000369748
• ENSP00000358763
• ENST00000445067
• ENSP00000437082
• ENST00000466741
• ENSP00000437086
• ENST00000524472
• ENSP00000432049

Symbol

• CHIL2
• YKL39
• YKL-39

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.9
protein domain	0.85
cell type or tissue	0.73
disease perturbation	0.49
small molecule perturbation	0.49

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.18   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 206   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.18   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0