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Tbio
SPEG
Striated muscle preferentially expressed protein kinase

Protein Summary
Description
Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. This gene encodes a protein with similarity to members of the myosin light chain kinase family. This protein family is required for myocyte cytoskeletal development. Along with the desmin gene, expression of this gene may be controlled by the desmin locus control region. Mutations in this gene are associated with centronuclear myopathy 5. [provided by RefSeq, Jun 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312358
  • ENSP00000311684
  • ENSG00000072195
  • ENST00000396686
  • ENSP00000379917
  • ENST00000396688
  • ENSP00000379919
  • ENST00000396689
  • ENSP00000379920

Symbol
  • APEG1
  • KIAA1297
  • BPEG
  • CNM5
  • APEG1
  • MYLK6
  • APEG-1
  • SPEGbeta
  • SPEGalpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.91
PubMedID
0.8
small molecule perturbation
0.79
transcription factor
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.12   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 71   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.12   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (118)
VAPB
Tbio
Novelty:  0.00542377
p_int:  0.997645629
p_ni:  2.04e-7
p_wrong:  0.002354167
Score:  0.188
Data Source:  BioPlex,STRINGDB
CALM2
Tclin
Novelty:  0.01876254
Score:  0.745
Data Source:  STRINGDB
CALM3
Tclin
Novelty:  0.00461552
Score:  0.745
Data Source:  STRINGDB
CALM1
Tclin
Novelty:  0.00308267
Score:  0.745
Data Source:  STRINGDB
ACTG2
Tbio
Novelty:  0.00304944
Score:  0.738
Data Source:  STRINGDB
IPP
Tbio
Novelty:  0.12841634
Score:  0.698
Data Source:  STRINGDB
RSPH3
Tdark
Novelty:  0.04470453
Score:  0.696
Data Source:  STRINGDB
RHBDL3
Tdark
Novelty:  0.22014815
Score:  0.677
Data Source:  STRINGDB
PEAR1
Tbio
Novelty:  0.02897414
Score:  0.674
Data Source:  STRINGDB
TNNC2
Tbio
Novelty:  0.07759506
Score:  0.646
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
3
4
88.8
creatinine measurement
1
2
2
85.6
electrocardiography
1
1
82
75.9
soluble triggering receptor expressed on myeloid cells 2 measurement
1
1
0
15744.7
53.3
vital capacity
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
4
88.8
creatinine measurement
2
85.6
electrocardiography
82
75.9
soluble triggering receptor expressed on myeloid cells 2 measurement
0
15744.7
53.3
vital capacity
1
40.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SPEG complex locus
743624
Macaque
SPEG complex locus
703645
Mouse
MGI:109282
11790
Rat
RGD:2124
363256
Dog
SPEG complex locus
VGNC:49703
478924
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SPEG complex locus
Macaque
SPEG complex locus
Mouse
Rat
Dog
SPEG complex locus
Publication Statistics
PubMed Score 70.12
PubMed score by year
PubTator Score 64.86
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title