SPEG
Striated muscle preferentially expressed protein kinase
Protein Summary
Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. This gene encodes a protein with similarity to members of the myosin light chain kinase family. This protein family is required for myocyte cytoskeletal development. Along with the desmin gene, expression of this gene may be controlled by the desmin locus control region. Mutations in this gene are associated with centronuclear myopathy 5. [provided by RefSeq, Jun 2016]
- ENST00000312358
- ENSP00000311684
- ENSG00000072195
- ENST00000396686
- ENSP00000379917
- ENST00000396688
- ENSP00000379919
- ENST00000396689
- ENSP00000379920
- APEG1
- KIAA1297
- BPEG
- CNM5
- APEG1
- MYLK6
- APEG-1
- SPEGbeta
- SPEGalpha
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
molecular function | 0.91 | ||
PubMedID | 0.8 | ||
small molecule perturbation | 0.79 | ||
transcription factor | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 70.12 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 71 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 70.12 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 71 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (118)
VAPB
Novelty: 0.00542377
p_int: 0.997645629
p_ni: 2.04e-7
p_wrong: 0.002354167
Score: 0.188
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (3)
Components (1)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
glomerular filtration rate | 3 | 3 | 4 | 88.8 | |||||
creatinine measurement | 1 | 2 | 2 | 85.6 | |||||
electrocardiography | 1 | 1 | 82 | 75.9 | |||||
soluble triggering receptor expressed on myeloid cells 2 measurement | 1 | 1 | 0 | 15744.7 | 53.3 | ||||
vital capacity | 1 | 1 | 1 | 40.7 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
glomerular filtration rate | 4 | 88.8 | |||||
creatinine measurement | 2 | 85.6 | |||||
electrocardiography | 82 | 75.9 | |||||
soluble triggering receptor expressed on myeloid cells 2 measurement | 0 | 15744.7 | 53.3 | ||||
vital capacity | 1 | 40.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | SPEG complex locus | 743624 | ||||||
Macaque | SPEG complex locus | 703645 | ||||||
Mouse | MGI:109282 | 11790 | ||||||
Rat | RGD:2124 | 363256 | ||||||
Dog | SPEG complex locus | VGNC:49703 | 478924 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | SPEG complex locus | |||||
Macaque | SPEG complex locus | |||||
Mouse | ||||||
Rat | ||||||
Dog | SPEG complex locus | |||||
Publication Statistics
PubMed Score 70.12
PubMed score by year
PubTator Score 64.86
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (21)
GeneRif Annotations (5)
Items per page:
0 of 0
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