SPEG
Striated muscle preferentially expressed protein kinase
Protein Summary
Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. This gene encodes a protein with similarity to members of the myosin light chain kinase family. This protein family is required for myocyte cytoskeletal development. Along with the desmin gene, expression of this gene may be controlled by the desmin locus control region. Mutations in this gene are associated with centronuclear myopathy 5. [provided by RefSeq, Jun 2016]
- ENST00000312358
- ENSP00000311684
- ENSG00000072195
- ENST00000396686
- ENSP00000379917
- ENST00000396688
- ENSP00000379919
- ENST00000396689
- ENSP00000379920
- APEG1
- KIAA1297
- BPEG
- CNM5
- APEG1
- MYLK6
- APEG-1
- SPEGbeta
- SPEGalpha
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
molecular function | 0.91 | ||
PubMedID | 0.8 | ||
small molecule perturbation | 0.79 | ||
transcription factor | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 86.98 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 71 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 86.98 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 71 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0