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Tbio
RAB30
Ras-related protein Rab-30

Protein Summary
Description
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260056
  • ENSP00000260056
  • ENSG00000137502
  • ENST00000527633
  • ENSP00000435089
  • ENST00000533486
  • ENSP00000435189
  • ENST00000534141
  • ENSP00000434974
  • ENST00000612684
  • ENSP00000478702
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.95
transcription factor perturbation
0.91
molecular function
0.9
kinase perturbation
0.88
histone modification site profile
0.86


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.39   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 244   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.39   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 244   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (122)
HTT
Tchem
Novelty:  0.00034051
p_int:  0.999995817
p_ni:  0.000004183
Score:  0.201
Data Source:  BioPlex,STRINGDB
CHML
Tbio
Family:  Enzyme
Novelty:  0.00509709
p_int:  0.999988783
p_ni:  0.000011203
p_wrong:  1.4e-8
Score:  0.923
Data Source:  BioPlex,STRINGDB
F8A1
Tbio
Novelty:  0.03481819
p_int:  0.999987976
p_ni:  1.7e-8
p_wrong:  0.000012008
Score:  0.303
Data Source:  BioPlex,STRINGDB
CHM
Tbio
Family:  Enzyme
Novelty:  0.00226278
p_int:  0.99996602
p_ni:  0.00003398
Score:  0.922
Data Source:  BioPlex,STRINGDB
USP4
Tchem
Family:  Enzyme
Novelty:  0.01101075
p_int:  0.999631557
p_ni:  0.000352587
p_wrong:  0.000015857
Data Source:  BioPlex
D2HGDH
Tbio
Family:  Enzyme
Novelty:  0.04618268
p_int:  0.999581755
p_ni:  0.000418231
p_wrong:  1.5e-8
Data Source:  BioPlex
RANGRF
Tbio
Family:  Enzyme
Novelty:  0.02750539
p_int:  0.999501882
p_ni:  0.00044823
p_wrong:  0.000049887
Data Source:  BioPlex
UHRF1BP1
Tbio
Novelty:  0.1588079
p_int:  0.999319369
p_ni:  0.000680631
Score:  0.221
Data Source:  BioPlex,STRINGDB
PHLDB3
Tdark
Novelty:  2.01921901
p_int:  0.996354264
p_ni:  0.003645736
Data Source:  BioPlex
TRAPPC10
Tbio
Novelty:  0.03433058
p_int:  0.987199755
p_ni:  0.012800245
Score:  0.235
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Intra-Golgi and retrograde Golgi-to-ER traffic (R-HSA-6811442)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Intra-Golgi traffic
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Intra-Golgi and retrograde Golgi-to-ER traffic
Intra-Golgi traffic
Membrane Trafficking
Metabolism of proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte percentage of leukocytes
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte percentage of leukocytes
1
31.4
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAB30, member RAS oncogene family
749006
Macaque
RAB30, member RAS oncogene family
701550
Mouse
MGI:1923235
75985
Rat
RGD:1309507
308821
Dog
RAB30, member RAS oncogene family
VGNC:45273
476787
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAB30, member RAS oncogene family
Macaque
RAB30, member RAS oncogene family
Mouse
Rat
Dog
RAB30, member RAS oncogene family
Publication Statistics
PubMed Score 9.39
PubMed score by year
PubTator Score 3.21
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title