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Tbio
EFNB3
Ephrin-B3

Protein Summary
Description
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity). (Microbial infection) Acts as a receptor for nipah virus and hendra virus. EFNB3, a member of the ephrin gene family, is important in brain development as well as in its maintenance. Moreover, since levels of EFNB3 expression were particularly high in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000226091
  • ENSP00000226091
  • ENSG00000108947

Symbol
  • EPLG8
  • LERK8
  • EFL6
  • EPLG8
  • LERK8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.83
molecular function
0.73
histone modification site profile
0.71
PubMedID
0.68
tissue sample
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.97   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 247   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.97   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 247   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (204)
1 – 10 of 204
MPP7
Tbio
Novelty:  1.59072481
p_int:  0.999999725
p_ni:  2.75e-7
Score:  0.214
Data Source:  BioPlex,STRINGDB
RGS3
Tbio
Novelty:  0.01749541
p_int:  0.999310283
p_ni:  0.000689716
p_wrong:  1e-9
Score:  0.866
Data Source:  BioPlex,STRINGDB
TNFSF8
Tbio
Novelty:  0.01292216
p_int:  0.998174847
p_ni:  0.00182515
p_wrong:  3e-9
Data Source:  BioPlex
FAM221B
Tdark
Novelty:  71
p_int:  0.996072754
p_ni:  0.003795222
p_wrong:  0.000132024
Score:  0.181
Data Source:  BioPlex,STRINGDB
DLG1
Tbio
Novelty:  0.0050926
p_int:  0.995640605
p_ni:  0.004359394
p_wrong:  1e-9
Score:  0.3
Data Source:  BioPlex,STRINGDB
TBC1D22A
Tbio
Novelty:  0.46374046
p_int:  0.994977193
p_ni:  0.0050228
p_wrong:  7e-9
Score:  0.196
Data Source:  BioPlex,STRINGDB
PKN3
Tchem
Family:  Kinase
Novelty:  0.0516816
p_int:  0.993635099
p_ni:  0.005756082
p_wrong:  0.000608819
Data Source:  BioPlex
TCAF2
Tbio
Family:  Enzyme
Novelty:  0.37070492
p_int:  0.992097945
p_ni:  0.007901018
p_wrong:  0.000001037
Data Source:  BioPlex
RTEL1
Tbio
Family:  Enzyme
Novelty:  0.00761538
p_int:  0.992058492
p_ni:  0.007941508
Data Source:  BioPlex
PLCD3
Tbio
Family:  Enzyme
Novelty:  0.04749421
p_int:  0.991776221
p_ni:  0.008223542
p_wrong:  2.37e-7
Score:  0.176
Data Source:  BioPlex,STRINGDB
Pathways (20)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPH-ephrin mediated repulsion of cells
Reactome
Ephrin signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
EPH-Ephrin signaling
EPH-ephrin mediated repulsion of cells
Ephrin signaling
GWAS Traits (49)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
9
20
27
99.9
sex hormone-binding globulin measurement
7
6
15
99.5
hormone measurement
2
3
1
57
94.8
serum non-albumin protein measurement
1
7
7
93.9
4
2
0
2.6
91.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
27
99.9
sex hormone-binding globulin measurement
15
99.5
hormone measurement
1
57
94.8
serum non-albumin protein measurement
7
93.9
0
2.6
91.5
Find similar targets by:
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:109196
13643
Rat
RGD:2541
360546
Dog
ephrin B3
VGNC:40230
607903
Horse
ephrin B3
VGNC:17451
100062080
Cow
ephrin B3
VGNC:28361
617714
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
ephrin B3
Horse
ephrin B3
Cow
ephrin B3
Publication Statistics
PubMed Score 85.97
PubMed score by year
PubTator Score 41.07
PubTator score by year