Protein Summary
Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell (PubMed:8673704). Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding (PubMed:26755705). This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
- ENST00000280200
- ENSP00000280200
- ENSG00000150637
- ENST00000582621
- ENSP00000461947
- DNAM1
- PTA1
- DNAM1
- DNAM-1
- TLiSA1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
phenotype | 0.77 | ||
gene perturbation | 0.74 | ||
cell type or tissue | 0.69 | ||
tissue sample | 0.69 | ||
disease | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 328.47 (req: < 5)
Gene RIFs: 131 (req: <= 3)
Antibodies: 734 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 328.47 (req: >= 5)
Gene RIFs: 131 (req: > 3)
Antibodies: 734 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0