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Tbio
CD226
CD226 antigen

Protein Summary
Description
Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell (PubMed:8673704). Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding (PubMed:26755705). This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280200
  • ENSP00000280200
  • ENSG00000150637
  • ENST00000582621
  • ENSP00000461947

Symbol
  • DNAM1
  • PTA1
  • DNAM1
  • DNAM-1
  • TLiSA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.77
gene perturbation
0.74
cell type or tissue
0.69
tissue sample
0.69
disease
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 302.28   (req: < 5)
Gene RIFs: 91   (req: <= 3)
Antibodies: 734   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 302.28   (req: >= 5)
Gene RIFs: 91   (req: > 3)
Antibodies: 734   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (201)
MAOB
Tclin
Family:  Enzyme
Novelty:  0.00030366
p_int:  0.999999857
p_ni:  2.4e-8
p_wrong:  1.19e-7
Data Source:  BioPlex
OR52N5
Tdark
Family:  oGPCR
Novelty:  6.7699115
p_int:  0.999998799
p_ni:  5.8e-8
p_wrong:  0.000001143
Data Source:  BioPlex
ZDHHC6
Tbio
Family:  Enzyme
Novelty:  0.17384821
p_int:  0.99994964
p_ni:  0.00005036
Data Source:  BioPlex
INTS7
Tdark
Novelty:  0.04592325
p_int:  0.99982139
p_ni:  0.00017861
Data Source:  BioPlex
EIF2B4
Tbio
Novelty:  0.05080792
p_int:  0.999722925
p_ni:  0.000277075
Data Source:  BioPlex
TMEM128
Tdark
Novelty:  5.15874803
p_int:  0.999651191
p_ni:  2.22e-7
p_wrong:  0.000348587
Data Source:  BioPlex
TTC7B
Tbio
Novelty:  0.22257455
p_int:  0.999381587
p_ni:  0.000239912
p_wrong:  0.0003785
Data Source:  BioPlex
THADA
Tbio
Novelty:  0.06983966
p_int:  0.998656645
p_ni:  0.001343355
Data Source:  BioPlex
ARL10
Tdark
Family:  Enzyme
Novelty:  1.16329406
p_int:  0.9981721
p_ni:  0.001827897
p_wrong:  3e-9
Data Source:  BioPlex
NF1
Tbio
Novelty:  0.00019092
p_int:  0.998083753
p_ni:  0.001916246
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
5
7
9
99.6
platelet crit
2
3
3
95.7
reticulocyte count
2
2
2
80
neutrophil count
2
2
2
76.2
reticulocyte measurement
3
1
3
76.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
9
99.6
platelet crit
3
95.7
reticulocyte count
2
80
neutrophil count
2
76.2
reticulocyte measurement
3
76.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD226 molecule
VGNC:13247
468577
Mouse
MGI:3039602
225825
Rat
RGD:1311513
307199
Dog
CD226 molecule
VGNC:38940
609196
Horse
CD226 molecule
VGNC:16253
100060036
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD226 molecule
Mouse
Rat
Dog
CD226 molecule
Horse
CD226 molecule
Publication Statistics
PubMed Score 302.28
PubMed score by year
PubTator Score 195.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title