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Tchem
NPY5R
Neuropeptide Y receptor type 5

Protein Summary
Description
Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders. The protein encoded by this gene is a receptor for neuropeptide Y and peptide YY. The encoded protein appears to be involved in regulating food intake, with defects in this gene being associated with eating disorders. Also, the encoded protein is involved in a pathway that protects neuroblastoma cells from chemotherapy-induced cell death, providing a possible therapeutic target against neuroblastoma. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338566
  • ENSP00000339377
  • ENSG00000164129
  • ENST00000506953
  • ENSP00000423474
  • ENST00000515560
  • ENSP00000423917

Symbol
  • NPYR5
  • NPYR5
  • NPY5-R
  • NPYY5-R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.68
ligand (protein)
0.68
biological process
0.63
cell line
0.62
cell type or tissue
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.35   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 256   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.35   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 256   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 702
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (24)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Protein-Protein Interactions (253)
1 – 10 of 253
NPY
Tbio
Novelty: 0.00014761
Score: 0.987
Data Source: Reactome,STRINGDB
PYY
Tbio
Novelty: 0.0007798
Score: 0.966
Data Source: Reactome,STRINGDB
GAL
Tbio
Novelty: 0.00057698
Score: 0.951
Data Source: STRINGDB
FPR1
Tchem
Family: GPCR
Novelty: 0.00150161
Score: 0.95
Data Source: STRINGDB
SST
Tbio
Novelty: 0.0000732
Score: 0.949
Data Source: STRINGDB
NPY1R
Tchem
Family: GPCR
Novelty: 0.00325172
Score: 0.944
Data Source: STRINGDB
PDYN
Tbio
Novelty: 0.00033852
Score: 0.942
Data Source: STRINGDB
POMC
Tbio
Novelty: 0.00002654
Score: 0.941
Data Source: STRINGDB
MCHR2
Tchem
Family: GPCR
Novelty: 0.01078171
Score: 0.935
Data Source: STRINGDB
RLN3
Tbio
Novelty: 0.01243441
Score: 0.932
Data Source: STRINGDB
Publication Statistics
PubMed Score  57.35

PubMed score by year
PubTator Score  76.71

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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