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Tchem
NPY5R
Neuropeptide Y receptor type 5

Protein Summary
Description
Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders. The protein encoded by this gene is a receptor for neuropeptide Y and peptide YY. The encoded protein appears to be involved in regulating food intake, with defects in this gene being associated with eating disorders. Also, the encoded protein is involved in a pathway that protects neuroblastoma cells from chemotherapy-induced cell death, providing a possible therapeutic target against neuroblastoma. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338566
  • ENSP00000339377
  • ENSG00000164129
  • ENST00000506953
  • ENSP00000423474
  • ENST00000515560
  • ENSP00000423917

Symbol
  • NPYR5
  • NPYR5
  • NPY5-R
  • NPYY5-R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.68
ligand (protein)
0.68
biological process
0.63
cell line
0.62
cell type or tissue
0.6


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.21   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 256   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.21   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 256   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 702
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuropeptide Y receptor Y5
VGNC:646
461582
Macaque
neuropeptide Y receptor Y5
574150
Mouse
MGI:108082
18168
Rat
RGD:3199
25340
Dog
neuropeptide Y receptor Y5
VGNC:54273
403712
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuropeptide Y receptor Y5
Macaque
neuropeptide Y receptor Y5
Mouse
Rat
Dog
neuropeptide Y receptor Y5
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15761-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (24)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Protein-Protein Interactions (253)
1 – 10 of 253
NPY
Tbio
Novelty: 0.00012637
Score: 0.987
Data Source: Reactome,STRINGDB
PYY
Tbio
Novelty: 0.00060997
Score: 0.966
Data Source: Reactome,STRINGDB
GAL
Tbio
Novelty: 0.0005132
Score: 0.951
Data Source: STRINGDB
FPR1
Tchem
Family: GPCR
Novelty: 0.00256884
Score: 0.95
Data Source: STRINGDB
SST
Tbio
Novelty: 0.00005944
Score: 0.949
Data Source: STRINGDB
NPY1R
Tchem
Family: GPCR
Novelty: 0.00438376
Score: 0.944
Data Source: STRINGDB
PDYN
Tbio
Novelty: 0.00039564
Score: 0.942
Data Source: STRINGDB
POMC
Tbio
Novelty: 0.00002436
Score: 0.941
Data Source: STRINGDB
MCHR2
Tchem
Family: GPCR
Novelty: 0.01191922
Score: 0.935
Data Source: STRINGDB
RLN3
Tbio
Novelty: 0.0107593
Score: 0.932
Data Source: STRINGDB
Publication Statistics
PubMed Score  44.21

PubMed score by year
PubTator Score  76.71

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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