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Tdark
GPR19
Probable G-protein coupled receptor 19

Protein Summary
Description
Orphan receptor.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332427
  • ENSP00000333744
  • ENSG00000183150
  • ENST00000540510
  • ENSP00000441832
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
gene perturbation
0.79
histone modification site profile
0.74
transcription factor binding site profile
0.74
tissue
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (22)
HSPA13
Tbio
Novelty:  0.03895652
Score:  0.626
Data Source:  STRINGDB
DHX40
Tdark
Family:  Enzyme
Novelty:  0.27906444
Score:  0.624
Data Source:  STRINGDB
SLC35F4
Tdark
Family:  Transporter
Novelty:  1.64700593
Score:  0.624
Data Source:  STRINGDB
CFAP70
Tdark
Novelty:  1.0349863
Score:  0.624
Data Source:  STRINGDB
DGKD
Tbio
Family:  Enzyme
Novelty:  0.03749316
Score:  0.6
Data Source:  STRINGDB
FHAD1
Tdark
Novelty:  0.55401917
Score:  0.545
Data Source:  STRINGDB
ACTR10
Tbio
Novelty:  0.11388846
Score:  0.544
Data Source:  STRINGDB
GPR82
Tdark
Family:  GPCR
Novelty:  0.39696704
Score:  0.525
Data Source:  STRINGDB
GPR22
Tbio
Family:  GPCR
Novelty:  0.1822753
Score:  0.512
Data Source:  STRINGDB
GPR31
Tbio
Family:  GPCR
Novelty:  0.09160693
Score:  0.474
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
5
5
5
96.6
1
3
0
1.2
84
appendicular lean mass
3
2
3
78.7
myeloid white cell count
2
2
2
76.2
mosaic loss of chromosome Y measurement
2
2
3
75.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
5
96.6
0
1.2
84
appendicular lean mass
3
78.7
myeloid white cell count
2
76.2
mosaic loss of chromosome Y measurement
3
75.9
Find similar targets by:
IDG Resources
Genetic Construct
GPR19-Tango
image for GPR19-Tango
Details:
  • Vector:  addgene66343
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • GPR19-Tango
Order Genetic Construct from:
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 19
VGNC:8599
740660
Macaque
G protein-coupled receptor 19
697072
Mouse
MGI:892973
14760
Rat
RGD:71045
312787
Dog
G protein-coupled receptor 19
VGNC:41424
100686071
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 19
Macaque
G protein-coupled receptor 19
Mouse
Rat
Dog
G protein-coupled receptor 19
Publication Statistics
PubTator Score 3.09
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title