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Tchem
MAPK11
Mitogen-activated protein kinase 11

Protein Summary
Description
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with those of MAPK14. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid indu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330651
  • ENSP00000333685
  • ENSG00000185386
  • ENST00000395764
  • ENSP00000379113

Symbol
  • PRKM11
  • SAPK2
  • SAPK2B
  • P38B
  • SAPK2
  • p38-2
  • PRKM11
  • SAPK2B
  • p38Beta
  • P38BETA2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.96
molecular function
0.96
pathway
0.87
protein domain
0.85
hub protein
0.71


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.62   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 464   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.62   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 464   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 38
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
mitogen-activated protein kinase 11
715794
Mouse
MGI:1338024
19094
Rat
RGD:1309340
689314
Horse
mitogen-activated protein kinase 11
VGNC:19956
100056278
Cow
mitogen-activated protein kinase 11
VGNC:31214
618906
Species
Name
OMA
EggNOG
Inparanoid
Macaque
mitogen-activated protein kinase 11
Mouse
Rat
Horse
mitogen-activated protein kinase 11
Cow
mitogen-activated protein kinase 11
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15759-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (178)
Activation of PPARGC1A (PGC-1alpha) by phosphorylation (R-HSA-2151209)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 62
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Reactome
Activation of the AP-1 family of transcription factors
Reactome
Axon guidance
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Activation of the AP-1 family of transcription factors
Axon guidance
Cellular Senescence
Cellular responses to external stimuli
Gene Ontology Terms (19)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (356)
1 – 10 of 356
MAPKAPK3
Tchem
Family: Kinase
Novelty: 0.02469147
p_int: 0.999999997
p_wrong: 3e-9
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
RPS6KA4
Tchem
Family: Kinase
Novelty: 0.05213255
p_int: 0.976626945
p_ni: 9.41e-7
p_wrong: 0.023372114
Score: 0.947
Data Source: BioPlex,STRINGDB
MAPKAPK2
Tchem
Family: Kinase
Novelty: 0.00486452
Score: 0.992
Data Source: Reactome,STRINGDB
ATF2
Tbio
Family: TF
Novelty: 0.00457832
Score: 0.985
Data Source: Reactome,STRINGDB
MAP2K6
Tchem
Family: Kinase
Novelty: 0.00569655
Score: 0.984
Data Source: Reactome,STRINGDB
MAP2K3
Tchem
Family: Kinase
Novelty: 0.00349605
Score: 0.983
Data Source: Reactome,STRINGDB
JUN
Tchem
Family: TF
Novelty: 0.00006856
Score: 0.979
Data Source: STRINGDB
DUSP16
Tbio
Family: Enzyme
Novelty: 0.02881973
Score: 0.974
Data Source: STRINGDB
TAB1
Tchem
Family: Kinase
Novelty: 0.00721424
Score: 0.973
Data Source: STRINGDB
MAPKAPK5
Tchem
Family: Kinase
Novelty: 0.01349079
Score: 0.968
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  153.62

PubMed score by year
PubTator Score  97.92

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer