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Tchem
MAPK11
Mitogen-activated protein kinase 11

Protein Summary
Description
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with those of MAPK14. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid indu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330651
  • ENSP00000333685
  • ENSG00000185386
  • ENST00000395764
  • ENSP00000379113

Symbol
  • PRKM11
  • SAPK2
  • SAPK2B
  • P38B
  • SAPK2
  • p38-2
  • PRKM11
  • SAPK2B
  • p38Beta
  • P38BETA2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.96
molecular function
0.96
pathway
0.87
protein domain
0.85
hub protein
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 184   (req: < 5)
Gene RIFs: 44   (req: <= 3)
Antibodies: 464   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 184   (req: >= 5)
Gene RIFs: 44   (req: > 3)
Antibodies: 464   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 42
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0