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Tchem
MAPK11
Mitogen-activated protein kinase 11

Protein Summary
Description
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with those of MAPK14. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid indu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330651
  • ENSP00000333685
  • ENSG00000185386
  • ENST00000395764
  • ENSP00000379113

Symbol
  • PRKM11
  • SAPK2
  • SAPK2B
  • P38B
  • SAPK2
  • p38-2
  • PRKM11
  • SAPK2B
  • p38Beta
  • P38BETA2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.96
molecular function
0.96
pathway
0.87
protein domain
0.85
hub protein
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.87   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 464   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.87   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 464   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 38
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (178)
Activation of PPARGC1A (PGC-1alpha) by phosphorylation (R-HSA-2151209)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 62
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Reactome
Activation of the AP-1 family of transcription factors
Reactome
Axon guidance
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Activation of the AP-1 family of transcription factors
Axon guidance
Cellular Senescence
Cellular responses to external stimuli
Gene Ontology Terms (19)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (356)
1 – 10 of 356
MAPKAPK3
Tchem
Family: Kinase
Novelty: 0.01845634
p_int: 0.999999997
p_wrong: 3e-9
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
RPS6KA4
Tchem
Family: Kinase
Novelty: 0.06941721
p_int: 0.976626945
p_ni: 9.41e-7
p_wrong: 0.023372114
Score: 0.947
Data Source: BioPlex,STRINGDB
MAPKAPK2
Tchem
Family: Kinase
Novelty: 0.00521234
Score: 0.992
Data Source: Reactome,STRINGDB
ATF2
Tbio
Family: TF
Novelty: 0.00562547
Score: 0.985
Data Source: Reactome,STRINGDB
MAP2K6
Tchem
Family: Kinase
Novelty: 0.00880457
Score: 0.984
Data Source: Reactome,STRINGDB
MAP2K3
Tchem
Family: Kinase
Novelty: 0.00438772
Score: 0.983
Data Source: Reactome,STRINGDB
JUN
Tchem
Family: TF
Novelty: 0.00013623
Score: 0.979
Data Source: STRINGDB
DUSP16
Tbio
Family: Enzyme
Novelty: 0.03854358
Score: 0.974
Data Source: STRINGDB
TAB1
Tchem
Family: Kinase
Novelty: 0.01006931
Score: 0.973
Data Source: STRINGDB
MAPKAPK5
Tchem
Family: Kinase
Novelty: 0.01278004
Score: 0.968
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  101.87

PubMed score by year
PubTator Score  97.92

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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