Tbio SLC1A5 Neutral amino acid transporter B(0)

Protein Summary

Description

Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids (PubMed:8702519, PubMed:29872227). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904). (Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114. (Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus. (Microbial infection) Acts as a cell surface receptor for type D simian retroviruses. The SLC1A5 gene encodes a sodium-dependent neutral amino acid transporter that can act as a receptor for RD114/type D retrovirus (Larriba et al., 2001 [PubMed 11781704]).[supplied by OMIM, Jan 2011]

Uniprot Accession IDs

• Q15758
• A8K9H5
• B4DR77
• B4DWS4
• B7ZB81
• D0EYG6
• E9PC01
• O95720
• Q96RL9
• Q9BWQ3
• Q9UNP2
• ATB(0)

Gene Name

• SLC1A5

Ensembl ID

• ENST00000412532
• ENSP00000397924
• ENSG00000105281
• ENST00000434726
• ENSP00000406532
• ENST00000542575
• ENSP00000444408

Symbol

• ASCT2
• M7V1
• RDR
• RDRC
• R16
• AAAT
• ATBO
• M7V1
• RDRC
• ASCT2
• M7VS1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.97
interacting protein	0.95
transcription factor binding site profile	0.92
transcription factor perturbation	0.88
PubMedID	0.84

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Neutral Amino Acid Transporter B(0)

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc1 Family Of Amino Acid Transporters / Alanine/serine/cysteine Transporter Subfamily / Neutral Amino Acid Transporter B(0)

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 819.44   (req: < 5)

Gene RIFs: 105   (req: <= 3)

Antibodies: 249   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 819.44   (req: >= 5)

Gene RIFs: 105   (req: > 3)

Antibodies: 249   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0