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Tbio
HERC1
Probable E3 ubiquitin-protein ligase HERC1

Protein Summary
Description
Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. This gen encodes a member of the HERC protein family. This protein stimulates guanine nucleotide exchange on ARF1 and Rab proteins. This protein may be involved in membrane transport processes. [provided by RefSeq, Mar 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000443617
  • ENSP00000390158
  • ENSG00000103657

Symbol
  • p532
  • p619
  • MDFPMR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
transcription factor binding site profile
0.85
kinase perturbation
0.84
histone modification site profile
0.78
transcription factor
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.57   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 47   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.57   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 47   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
81.5
1
1
1
76.1
smoking status measurement
1
1
1
63.1
wellbeing measurement
2
1
2
58.4
depressive symptom measurement
1
1
1
46.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
81.5
1
76.1
smoking status measurement
1
63.1
wellbeing measurement
2
58.4
depressive symptom measurement
1
46.7
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (6)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Protein-Protein Interactions (324)
1 – 10 of 324
IFIT1B
Tdark
Novelty: 0.29249041
p_int: 0.999988683
p_ni: 0.000011317
Score: 0.197
Data Source: BioPlex,STRINGDB
WDFY3
Tbio
Novelty: 0.01670166
p_int: 0.999945892
p_ni: 0.000054108
Score: 0.476
Data Source: BioPlex,STRINGDB
DHX40
Tdark
Family: Enzyme
Novelty: 0.27906444
p_int: 0.999806434
p_ni: 0.000193566
Data Source: BioPlex
TIGD6
Tdark
Novelty: 4.01176838
p_int: 0.999696188
p_ni: 0.000303812
Score: 0.188
Data Source: BioPlex,STRINGDB
CCDC65
Tdark
Novelty: 0.05107666
p_int: 0.999036999
p_ni: 0.000963
Score: 0.165
Data Source: BioPlex,STRINGDB
GCNT3
Tbio
Family: Enzyme
Novelty: 0.04356924
p_int: 0.999030519
p_ni: 0.000969481
Score: 0.181
Data Source: BioPlex,STRINGDB
TRPC4AP
Tbio
Novelty: 0.02170224
p_int: 0.998871632
p_ni: 0.001128368
Data Source: BioPlex
SSH3
Tbio
Family: Enzyme
Novelty: 0.11388661
p_int: 0.998753774
p_ni: 0.001246226
Score: 0.19
Data Source: BioPlex,STRINGDB
MORC1
Tbio
Novelty: 0.0182807
p_int: 0.99861676
p_ni: 0.00138324
p_wrong: 1e-9
Score: 0.213
Data Source: BioPlex,STRINGDB
TFDP3
Tbio
Family: TF
Novelty: 0.00223003
p_int: 0.998289311
p_ni: 0.001710688
Score: 0.151
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  15.57

PubMed score by year
PubTator Score  25.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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