Tbio HERC1 Probable E3 ubiquitin-protein ligase HERC1

Protein Summary

Description

Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. This gen encodes a member of the HERC protein family. This protein stimulates guanine nucleotide exchange on ARF1 and Rab proteins. This protein may be involved in membrane transport processes. [provided by RefSeq, Mar 2012]

Uniprot Accession IDs

• Q15751
• Q8IW65

Gene Name

• HERC1

Ensembl ID

• ENST00000443617
• ENSP00000390158
• ENSG00000103657

Symbol

• p532
• p619
• MDFPMR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
transcription factor binding site profile	0.85
kinase perturbation	0.84
histone modification site profile	0.78
transcription factor	0.67

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Probable E3 Ubiquitin-protein Ligase Herc1

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Probable E3 Ubiquitin-protein Ligase Herc1

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Probable E3 Ubiquitin-protein Ligase Herc1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.83   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 47   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.83   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 47   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0