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Tchem
TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

Protein Summary
Description
May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis. The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Altern ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216160
  • ENSP00000216160
  • ENSG00000100324
  • ENST00000331454
  • ENSP00000333049

Symbol
  • MAP3K7IP1
  • 3'-Tab1
  • MAP3K7IP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.94
biological process
0.9
transcription factor
0.9
transcription factor binding site profile
0.84
pathway
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.82   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 573   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.82   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 573   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
2
2
83.6
von Willebrand factor measurement
1
1
2
62.7
cognitive function measurement
3
1
3
50.6
mathematical ability
3
1
3
50.3
serum IgG glycosylation measurement
1
1
1
44
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
83.6
von Willebrand factor measurement
2
62.7
cognitive function measurement
3
50.6
mathematical ability
3
50.3
serum IgG glycosylation measurement
1
44
Protein Data Bank (30)
1 – 5 of 30
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (97)
C-type lectin receptors (CLRs) (R-HSA-5621481)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 45
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) signaling
Reactome
Cytokine Signaling in Immune system
Reactome
Death Receptor Signalling
Reactome
Deubiquitination
Name
Explore in Pharos
Explore in Source
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) signaling
Cytokine Signaling in Immune system
Death Receptor Signalling
Deubiquitination
Gene Ontology Terms (27)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (186)
1 – 10 of 186
TAB3
Tbio
Family: Enzyme
Novelty: 0.01768638
p_int: 0.999999997
p_ni: 3e-9
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
MAP3K7
Tchem
Family: Kinase
Novelty: 0.00540177
p_int: 0.999999992
p_ni: 9e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
TAB2
Tbio
Family: Enzyme
Novelty: 0.00635786
p_int: 0.999999992
p_ni: 8e-9
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
EMILIN1
Tbio
Novelty: 0.02550566
p_int: 0.999981858
p_ni: 0.000018142
Data Source: BioPlex
SYNC
Tbio
Novelty: 0.04605223
p_int: 0.999773299
p_ni: 0.000226701
Data Source: BioPlex
MORF4L1
Tbio
Family: Epigenetic
Novelty: 0.01696001
p_int: 0.999770708
p_ni: 0.000229292
Score: 0.187
Data Source: BioPlex,STRINGDB
AARSD1
Tdark
Novelty: 0.75372406
p_int: 0.999627301
p_ni: 0.000372699
Data Source: BioPlex
SERPINB2
Tbio
Novelty: 0.00204345
p_int: 0.998823661
p_ni: 0.001176339
Score: 0.153
Data Source: BioPlex,STRINGDB
SCRN1
Tbio
Family: Enzyme
Novelty: 0.08315012
p_int: 0.998797399
p_ni: 0.001202601
Score: 0.152
Data Source: BioPlex,STRINGDB
CCDC102B
Tdark
Novelty: 0.28075569
p_int: 0.997927605
p_ni: 0.002072394
Data Source: BioPlex
Publication Statistics
PubMed Score  124.82

PubMed score by year
PubTator Score  12.12

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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