You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
MYLK
Myosin light chain kinase, smooth muscle

Protein Summary
Description
Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346322
  • ENSP00000320622
  • ENSG00000065534
  • ENST00000354792
  • ENSP00000346846
  • ENST00000359169
  • ENSP00000352088
  • ENST00000360304
  • ENSP00000353452
  • ENST00000360772
  • ENSP00000354004
  • ENST00000418370
  • ENSP00000428967
  • ENST00000475616
  • ENSP00000418335
  • ENST00000578202
  • ENSP00000463691
  • ENST00000583087
  • ENSP00000462118

Symbol
  • MLCK
  • MLCK1
  • MYLK1
  • KRP
  • AAT7
  • MLCK
  • MLCK1
  • MYLK1
  • smMLCK
  • MLCK108
  • MLCK210
  • MSTP083
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.98
kinase
0.97
kinase perturbation
0.96
transcription factor perturbation
0.96


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 974.64   (req: < 5)
Gene RIFs: 80   (req: <= 3)
Antibodies: 328   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 974.64   (req: >= 5)
Gene RIFs: 80   (req: > 3)
Antibodies: 328   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
sunitinib
Rendered image for sunitinib
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
60.2
body mass index
1
1
1
48.5
intelligence
2
2
1
5.6
37.3
tea consumption measurement
1
1
1
35
coffee consumption measurement
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
60.2
body mass index
1
48.5
intelligence
1
5.6
37.3
tea consumption measurement
1
35
coffee consumption measurement
1
35
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myosin light chain kinase
VGNC:2433
101057233
Macaque
myosin light chain kinase
715422
Mouse
MGI:894806
107589
Rat
RGD:1310915
288057
Dog
myosin light chain kinase
VGNC:43549
488012
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myosin light chain kinase
Macaque
myosin light chain kinase
Mouse
Rat
Dog
myosin light chain kinase
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15746-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (26)
Muscle contraction (R-HSA-397014)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Muscle contraction
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases activate PAKs
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Muscle contraction
RHO GTPase Effectors
RHO GTPases activate PAKs
Signal Transduction
Signaling by Rho GTPases
Gene Ontology Terms (24)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (178)
1 – 10 of 178
CALM1
Tclin
Novelty:  0.00308267
Score:  0.998
Data Source:  Reactome,STRINGDB
MYL9
Tbio
Novelty:  0.00309239
Score:  0.997
Data Source:  Reactome,STRINGDB
MYL12A
Tbio
Novelty:  0.00944255
Score:  0.996
Data Source:  STRINGDB
MYL12B
Tbio
Novelty:  0.00999083
Score:  0.993
Data Source:  Reactome,STRINGDB
MYL2
Tbio
Novelty:  0.0018887
Score:  0.992
Data Source:  STRINGDB
MYL6B
Tbio
Novelty:  0.01292785
Score:  0.992
Data Source:  STRINGDB
MYL5
Tbio
Novelty:  0.012802
Score:  0.992
Data Source:  STRINGDB
MYL10
Tdark
Novelty:  0.01378575
Score:  0.992
Data Source:  STRINGDB
MYL6
Tbio
Novelty:  0.00594485
Score:  0.991
Data Source:  Reactome,STRINGDB
CALM3
Tclin
Novelty:  0.00461552
Score:  0.991
Data Source:  STRINGDB
Publication Statistics
PubMed Score  974.64

PubMed score by year
PubTator Score  793.36

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: