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Tchem
MYLK
Myosin light chain kinase, smooth muscle

Protein Summary
Description
Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346322
  • ENSP00000320622
  • ENSG00000065534
  • ENST00000354792
  • ENSP00000346846
  • ENST00000359169
  • ENSP00000352088
  • ENST00000360304
  • ENSP00000353452
  • ENST00000360772
  • ENSP00000354004
  • ENST00000418370
  • ENSP00000428967
  • ENST00000475616
  • ENSP00000418335
  • ENST00000578202
  • ENSP00000463691
  • ENST00000583087
  • ENSP00000462118

Symbol
  • MLCK
  • MLCK1
  • MYLK1
  • KRP
  • AAT7
  • MLCK
  • MLCK1
  • MYLK1
  • smMLCK
  • MLCK108
  • MLCK210
  • MSTP083
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.98
kinase
0.97
kinase perturbation
0.96
transcription factor perturbation
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1100.66   (req: < 5)
Gene RIFs: 98   (req: <= 3)
Antibodies: 328   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1100.66   (req: >= 5)
Gene RIFs: 98   (req: > 3)
Antibodies: 328   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1