Tbio CEBPE CCAAT/enhancer-binding protein epsilon

Protein Summary

Description

Transcriptional activator (PubMed:26019275). C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte-myelocyte transition in myeloid differentiation (PubMed:10359588). The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-delta. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with Specific Granule Deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q15744
• Q15745
• Q8IYI2
• Q99803
• C/EBP epsilon

Gene Name

• CEBPE

Ensembl ID

• ENST00000206513
• ENSP00000206513
• ENSG00000092067

Symbol

• CRP1
• C/EBP-epsilon

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.88
biological process	0.77
cell type or tissue	0.7
transcription factor binding site profile	0.63
cell line	0.51

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Basic Leucine Zipper Transcription Factor / Ccaat/enhancer-binding Protein Epsilon

Protein / Nucleic Acid Binding / Ccaat/enhancer-binding Protein Epsilon

DTO Classes

Protein / Transcription Factor / Basic Leucine Zipper Transcription Factor / Ccaat/enhancer-binding Protein Epsilon

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.94   (req: < 5)

Gene RIFs: 55   (req: <= 3)

Antibodies: 340   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.94   (req: >= 5)

Gene RIFs: 55   (req: > 3)

Antibodies: 340   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0