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Tchem
GPR68
Ovarian cancer G-protein coupled receptor 1

Protein Summary
Description
Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer (By similarity). The protein encoded by this gene is a G protein-coupled receptor for sphingosylphosphorylcholine. The encoded protein is a proton-sensing receptor, inactive at pH 7.8 but active at pH 6.8. Mutations in this gene are a cause of amelogenesis imperfecta. [provided by RefSeq, Feb 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000531499
  • ENSP00000434045
  • ENSG00000119714
  • ENST00000535815
  • ENSP00000440797

Symbol
  • OGR1
  • OGR1
  • AI2A6
  • GPR12A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.66
tissue sample
0.65
cell type or tissue
0.64
histone modification site profile
0.63
transcription factor
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.49   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 279   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.49   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 279   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
ogerin
chemical structure image
Pathways (8)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Signal Transduction
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (201)
1 – 10 of 201
GNG11
Tbio
Novelty: 0.14332397
Score: 0.943
Data Source: STRINGDB
GNA14
Tbio
Novelty: 0.12434273
Score: 0.929
Data Source: STRINGDB
LPAR3
Tchem
Family: GPCR
Novelty: 0.00724581
Score: 0.928
Data Source: STRINGDB
GPR39
Tchem
Family: GPCR
Novelty: 0.01528618
Score: 0.926
Data Source: STRINGDB
CASR
Tclin
Family: GPCR
Novelty: 0.00066875
Score: 0.921
Data Source: STRINGDB
GPR132
Tchem
Family: GPCR
Novelty: 0.00189182
Score: 0.92
Data Source: STRINGDB
PTAFR
Tchem
Family: GPCR
Novelty: 0.00890235
Score: 0.919
Data Source: STRINGDB
GNAQ
Tbio
Novelty: 0.00176666
Score: 0.919
Data Source: STRINGDB
GNA15
Tbio
Novelty: 0.0018171
Score: 0.916
Data Source: STRINGDB
GNG3
Tbio
Novelty: 0.16248863
Score: 0.916
Data Source: STRINGDB
Publication Statistics
PubMed Score  62.49

PubMed score by year
PubTator Score  47.78

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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