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Tbio
NAB2
NGFI-A-binding protein 2

Protein Summary
Description
Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity). This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300131
  • ENSP00000300131
  • ENSG00000166886
  • ENST00000342556
  • ENSP00000341491

Symbol
  • MADER
  • MADER
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.88
transcription factor
0.81
transcription factor perturbation
0.8
disease perturbation
0.79
PubMedID
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.55   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 339   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.55   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 339   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
1
1
66.2
insomnia measurement
3
1
0
1
64.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
66.2
insomnia measurement
0
1
64.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NGFI-A binding protein 2
VGNC:8469
452004
Macaque
NGFI-A binding protein 2
714209
Mouse
MGI:107563
17937
Rat
RGD:1311712
314910
Dog
NGFI-A binding protein 2
VGNC:43601
481122
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NGFI-A binding protein 2
Macaque
NGFI-A binding protein 2
Mouse
Rat
Dog
NGFI-A binding protein 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q15742-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (44)
1 – 10 of 44
NAB1
Tbio
Novelty: 0.03811946
p_int: 0.999999686
p_ni: 2.67e-7
p_wrong: 4.7e-8
Score: 0.36
Data Source: BioPlex,STRINGDB
NBEA
Tbio
Novelty: 0.02583687
p_int: 0.999977521
p_ni: 0.000022163
p_wrong: 3.16e-7
Score: 0.243
Data Source: BioPlex,STRINGDB
GRN
Tbio
Novelty: 0.00096395
p_int: 0.995135497
p_ni: 0.004864491
p_wrong: 1.2e-8
Data Source: BioPlex
C9orf78
Tdark
Novelty: 0.63248782
p_int: 0.990494044
p_ni: 0.009503277
p_wrong: 0.000002679
Score: 0.197
Data Source: BioPlex,STRINGDB
CUEDC2
Tbio
Novelty: 0.07403123
p_int: 0.986782299
p_ni: 0.013177241
p_wrong: 0.00004046
Score: 0.197
Data Source: BioPlex,STRINGDB
TNIP1
Tbio
Novelty: 0.0147254
p_int: 0.966666936
p_ni: 0.033333064
Score: 0.19
Data Source: BioPlex,STRINGDB
POLD2
Tbio
Family: Enzyme
Novelty: 0.05932998
p_int: 0.770994951
p_ni: 0.228969995
p_wrong: 0.000035054
Score: 0.188
Data Source: BioPlex,STRINGDB
EGR1
Tbio
Family: TF
Novelty: 0.00039994
Score: 0.911
Data Source: STRINGDB
EGR2
Tbio
Family: TF
Novelty: 0.00215433
Score: 0.893
Data Source: STRINGDB
EGR3
Tbio
Family: TF
Novelty: 0.00766779
Score: 0.83
Data Source: STRINGDB
Publication Statistics
PubMed Score  104.55

PubMed score by year
PubTator Score  72.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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