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Tbio
NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

Protein Summary
Description
Involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis. The protein encoded by this gene is localized in the endoplasmic reticulum and is involved in cholesterol biosynthesis. Mutations in this gene are associated with CHILD syndrome, which is a X-linked dominant disorder of lipid metabolism with disturbed cholesterol biosynthesis, and typically lethal in males. Alternatively spliced transcript variants with differing 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370274
  • ENSP00000359297
  • ENSG00000147383
  • ENST00000440023
  • ENSP00000391854

Symbol
  • H105E3
  • H105E3
  • XAP104
  • SDR31E1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
disease perturbation
0.9
co-expressed gene
0.89
histone modification site profile
0.84
transcription factor perturbation
0.8


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.99   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.99   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NAD(P) dependent steroid dehydrogenase-like
465960
Macaque
NAD(P) dependent steroid dehydrogenase-like
693333
Mouse
MGI:1099438
18194
Rat
RGD:1359337
309262
Dog
NAD(P) dependent steroid dehydrogenase-like
481079
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NAD(P) dependent steroid dehydrogenase-like
Macaque
NAD(P) dependent steroid dehydrogenase-like
Mouse
Rat
Dog
NAD(P) dependent steroid dehydrogenase-like
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q15738-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (35)
Cholesterol biosynthesis (R-HSA-191273)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cholesterol biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Name
Explore in Pharos
Explore in Source
Cholesterol biosynthesis
Metabolism
Metabolism of lipids
Metabolism of steroids
Gene Ontology Terms (16)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (105)
1 – 10 of 105
AK4
Tbio
Family: Kinase
Novelty: 0.00977619
p_int: 0.95950034
p_ni: 0.040498004
p_wrong: 0.000001656
Data Source: BioPlex
USP47
Tchem
Family: Enzyme
Novelty: 0.07579226
p_int: 0.95404097
p_ni: 0.045958632
p_wrong: 3.99e-7
Score: 0.187
Data Source: BioPlex,STRINGDB
MSMO1
Tbio
Family: Enzyme
Novelty: 0.01263528
Score: 0.999
Data Source: STRINGDB
HSD17B7
Tchem
Family: Enzyme
Novelty: 0.04295724
Score: 0.996
Data Source: STRINGDB
SQLE
Tchem
Family: Enzyme
Novelty: 0.0059338
Score: 0.993
Data Source: STRINGDB
LSS
Tchem
Family: Enzyme
Novelty: 0.00735187
Score: 0.992
Data Source: STRINGDB
CYP51A1
Tchem
Family: Enzyme
Novelty: 0.00127373
Score: 0.985
Data Source: STRINGDB
FDFT1
Tchem
Family: Enzyme
Novelty: 0.00225882
Score: 0.973
Data Source: STRINGDB
HMGCS1
Tchem
Family: Enzyme
Novelty: 0.01089288
Score: 0.972
Data Source: STRINGDB
IDI1
Tchem
Family: Enzyme
Novelty: 0.01145181
Score: 0.972
Data Source: STRINGDB
Publication Statistics
PubMed Score  62.99

PubMed score by year
PubTator Score  40.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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