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Tbio
INPP5J
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A

Protein Classes
Protein Summary
Description
Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331075
  • ENSP00000333262
  • ENSG00000185133
  • ENST00000400294
  • ENSP00000383150
  • ENST00000404390
  • ENSP00000384534
  • ENST00000405300
  • ENSP00000384596

Symbol
  • PIB5PA
  • PIPP
  • PIPP
  • INPP5
  • PIB5PA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.76
gene perturbation
0.7
molecular function
0.7
pathway
0.7
disease perturbation
0.68


Related Tools
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GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.9   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 185   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.9   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
1
1
1
28.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
1
28.4
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inositol polyphosphate-5-phosphatase J
VGNC:7341
458767
Macaque
inositol polyphosphate-5-phosphatase J
718308
Mouse
MGI:2158663
170835
Rat
RGD:620541
171088
Dog
inositol polyphosphate-5-phosphatase J
VGNC:42035
486360
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inositol polyphosphate-5-phosphatase J
Macaque
inositol polyphosphate-5-phosphatase J
Mouse
Rat
Dog
inositol polyphosphate-5-phosphatase J
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q15735-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (17)
Inositol phosphate metabolism (R-HSA-1483249)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Inositol phosphate metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Name
Explore in Pharos
Explore in Source
Inositol phosphate metabolism
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Gene Ontology Terms (19)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (40)
1 – 10 of 40
INPP4A
Tbio
Family: Enzyme
Novelty: 0.03714963
Score: 0.958
Data Source: STRINGDB
INPP4B
Tbio
Family: Enzyme
Novelty: 0.02053228
Score: 0.955
Data Source: STRINGDB
SACM1L
Tbio
Family: Enzyme
Novelty: 0.00499867
Score: 0.948
Data Source: STRINGDB
INPP5A
Tchem
Family: Enzyme
Novelty: 0.03249263
Score: 0.948
Data Source: STRINGDB
INPP1
Tbio
Family: Enzyme
Novelty: 0.05426301
Score: 0.936
Data Source: STRINGDB
ITPK1
Tbio
Family: Kinase
Novelty: 0.02790263
Score: 0.934
Data Source: STRINGDB
PTEN
Tchem
Family: Enzyme
Novelty: 0.00013818
Score: 0.928
Data Source: STRINGDB
ITPKA
Tchem
Family: Kinase
Novelty: 0.02901348
Score: 0.921
Data Source: STRINGDB
TPTE2
Tbio
Family: Enzyme
Novelty: 0.04710658
Score: 0.919
Data Source: STRINGDB
ITPKB
Tchem
Family: Kinase
Novelty: 0.02397335
Score: 0.915
Data Source: STRINGDB
Publication Statistics
PubMed Score  16.90

PubMed score by year
PubTator Score  36.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer