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Tbio
KISS1
Metastasis-suppressor KiSS-1

Protein Summary
Description
Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367194
  • ENSP00000356162
  • ENSG00000170498

Symbol
  • HH13
  • KiSS-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.95
cell type or tissue
0.73
chemical
0.53
pathway
0.5
disease
0.49


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1300.59   (req: < 5)
Gene RIFs: 209   (req: <= 3)
Antibodies: 300   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1300.59   (req: >= 5)
Gene RIFs: 209   (req: > 3)
Antibodies: 300   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
1
2
93.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
93.8
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
KiSS-1 metastasis-suppressor
457654
Macaque
KiSS-1 metastasis-suppressor
574306
Mouse
MGI:2663985
280287
Rat
RGD:727850
289023
Horse
KiSS-1 metastasis suppressor
VGNC:19432
100054297
Species
Name
OMA
EggNOG
Inparanoid
Chimp
KiSS-1 metastasis-suppressor
Macaque
KiSS-1 metastasis-suppressor
Mouse
Rat
Horse
KiSS-1 metastasis suppressor
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q15726-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Gene Ontology Terms (17)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (244)
1 – 10 of 244
VARS2
Tbio
Family: Enzyme
Novelty: 0.00941946
p_int: 0.999999988
p_ni: 1.1e-8
Data Source: BioPlex
KLHL15
Tbio
Novelty: 0.54712519
p_int: 0.98311583
p_ni: 0.01688417
Data Source: BioPlex
KLHL26
Tdark
Novelty: 1.53240393
p_int: 0.944104225
p_ni: 0.055895775
Data Source: BioPlex
FKBP10
Tbio
Family: Enzyme
Novelty: 0.01512539
p_int: 0.942562387
p_ni: 0.057437613
Data Source: BioPlex
KLHL22
Tbio
Novelty: 0.24456252
p_int: 0.843685414
p_ni: 0.156314586
Data Source: BioPlex
KISS1R
Tchem
Family: GPCR
Novelty: 0.0026282
Score: 0.997
Data Source: Reactome,STRINGDB
GNRH1
Tbio
Novelty: 0.00020807
Score: 0.995
Data Source: STRINGDB
TAC3
Tchem
Novelty: 0.001685
Score: 0.988
Data Source: STRINGDB
GNRHR
Tclin
Family: GPCR
Novelty: 0.00203671
Score: 0.982
Data Source: STRINGDB
TACR3
Tchem
Family: GPCR
Novelty: 0.00351352
Score: 0.978
Data Source: STRINGDB
Publication Statistics
PubMed Score  1300.59

PubMed score by year
PubTator Score  310.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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