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Tchem
LTB4R
Leukotriene B4 receptor 1

Protein Summary
Description
Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345363
  • ENSP00000307445
  • ENSG00000213903
  • ENST00000396782
  • ENSP00000380002
  • ENST00000396789
  • ENSP00000380008
  • ENST00000646659
  • ENSP00000495785
  • ENSG00000285456
  • ENST00000646739
  • ENSP00000494730
  • ENST00000647085
  • ENSP00000495466

Symbol
  • BLT
  • BLT1
  • BLTR
  • CMKRL1
  • GPR16
  • P2RY7
  • BLT1
  • BLTR
  • P2Y7
  • GPR16
  • LTBR1
  • P2RY7
  • CMKRL1
  • LTB4R1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.71
PubMedID
0.7
gene perturbation
0.64
transcription factor perturbation
0.61
ligand (chemical)
0.59


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 303   (req: < 5)
Gene RIFs: 50   (req: <= 3)
Antibodies: 506   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 303   (req: >= 5)
Gene RIFs: 50   (req: > 3)
Antibodies: 506   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 179
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
masoprocol
chemical structure image
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
leukotriene B4 receptor
716055
Mouse
MGI:1309472
16995
Rat
RGD:620410
59264
Dog
leukotriene B4 receptor
VGNC:42855
106559146
Horse
leukotriene B4 receptor [Source:HGNC Symbol;Acc:HGNC:6713]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
leukotriene B4 receptor
Mouse
Rat
Dog
leukotriene B4 receptor
Horse
leukotriene B4 receptor [Source:HGNC Symbol;Acc:HGNC:6713]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q15722-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (25)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Eicosanoid ligand-binding receptors
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Eicosanoid ligand-binding receptors
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (14)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (203)
1 – 10 of 203
TBXA2R
Tclin
Family: GPCR
Novelty: 0.00571066
Score: 0.957
Data Source: STRINGDB
GNA15
Tbio
Novelty: 0.00159196
Score: 0.948
Data Source: STRINGDB
GRK2
Tchem
Family: Kinase
Novelty: 0.00200696
Score: 0.947
Data Source: STRINGDB
GRK5
Tchem
Family: Kinase
Novelty: 0.01108012
Score: 0.946
Data Source: STRINGDB
GRM5
Tchem
Family: GPCR
Novelty: 0.00062552
Score: 0.937
Data Source: STRINGDB
PTGER1
Tclin
Family: GPCR
Novelty: 0.0013716
Score: 0.933
Data Source: STRINGDB
CCK
Tbio
Novelty: 0.00012268
Score: 0.932
Data Source: STRINGDB
GNG10
Tdark
Novelty: 0.37659459
Score: 0.931
Data Source: STRINGDB
NTS
Tbio
Novelty: 0.00033201
Score: 0.93
Data Source: STRINGDB
PTAFR
Tchem
Family: GPCR
Novelty: 0.00755426
Score: 0.929
Data Source: STRINGDB
Publication Statistics
PubMed Score  303.00

PubMed score by year
PubTator Score  180.93

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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