Tchem ELAVL1 ELAV-like protein 1

Protein Summary

Description

RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462). Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:8626503, PubMed:17632515, PubMed:18285462, PubMed:23519412, PubMed:14731398). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR (PubMed:29180010). The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. [provided by RefSeq, Sep 2012]

Uniprot Accession IDs

• Q15717
• B4DVB8
• Q53XN6
• Q9BTT1

Gene Name

• ELAVL1

Ensembl ID

• ENST00000407627
• ENSP00000385269
• ENSG00000066044
• ENST00000596459
• ENSP00000472197

Symbol

• HUR
• HUR
• Hua
• MelG
• ELAV1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
interacting protein	1
protein complex	0.99
hub protein	0.95
biological term	0.93

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1049.58   (req: < 5)

Gene RIFs: 356   (req: <= 3)

Antibodies: 433   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1049.58   (req: >= 5)

Gene RIFs: 356   (req: > 3)

Antibodies: 433   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

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Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Active Ligands (16)

Explore Active Ligands

1 – 10 of 16

Dihydrotanshinone I

ELAVL1Tchem

pKi : 7.3

Dehydromutactin

ELAVL1Tchem

pKd : 8.05

CHEMBL1240928

ELAVL1Tchem

pKd : 6.38

3-phenyl-1-(phenylsulfonyl)-1H-indole-4,5-dione

ELAVL1Tchem

pKi : 7.89

CHEMBL4064932

ELAVL1Tchem

pKi : 7.82

CHEMBL4095060

ELAVL1Tchem

pKi : 7.39

CHEMBL4100171

ELAVL1Tchem

pKi : 7.32

CHEMBL4105230

ELAVL1Tchem

pKi : 7.26

1-(methylsulfonyl)-3-phenyl-1H-indole-4,5-dione

ELAVL1Tchem

pKi : 7.25

CHEMBL4094161

ELAVL1Tchem

pKi : 7.09

Protein-Protein Interactions (500)

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1 – 10 of 500

• See Interactions on String-DB

PTBP1

Tbio

Novelty:  0.00184728

Score:  0.999

Data Source:  STRINGDB

HNRNPK

Tbio

Novelty:  0.00354731

Score:  0.998

Data Source:  STRINGDB

CDC5L

Tbio

Family:  TF

Novelty:  0.00663599

Score:  0.998

Data Source:  STRINGDB

HNRNPC

Tbio

Novelty:  0.00136097

Score:  0.998

Data Source:  STRINGDB

SRSF1

Tbio

Novelty:  0.00074446

Score:  0.997

Data Source:  STRINGDB

HNRNPH1

Tbio

Novelty:  0.01273351

Score:  0.997

Data Source:  STRINGDB

TRA2B

Tbio

Novelty:  0.0146833

Score:  0.997

Data Source:  STRINGDB

HNRNPA2B1

Tbio

Novelty:  0.00404935

Score:  0.997

Data Source:  STRINGDB

HNRNPA1

Tchem

Novelty:  0.0020871

Score:  0.997

Data Source:  STRINGDB

SRSF3

Tbio

Novelty:  0.01015895

Score:  0.997

Data Source:  STRINGDB

Pathways (22)

Reactome (6)

KEGG (2)

PathwayCommons (1)

WikiPathways (13)

HuR (ELAVL1) binds and stabilizes mRNA (R-HSA-450520)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	HuR (ELAVL1) binds and stabilizes mRNA	10 targets	R-HSA-450520
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
Reactome	Regulation of mRNA stability by proteins that bind AU-rich elements	90 targets	R-HSA-450531
Reactome	mRNA Splicing	188 targets	R-HSA-72172

Name	Explore in Pharos	Explore in Source
HuR (ELAVL1) binds and stabilizes mRNA	10 targets	R-HSA-450520
Metabolism of RNA	686 targets	R-HSA-8953854
Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
Regulation of mRNA stability by proteins that bind AU-rich elements	90 targets	R-HSA-450531
mRNA Splicing	188 targets	R-HSA-72172

Gene Ontology Terms (27)

Functions (9)

Components (9)

Processes (9)

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10

1 – 9 of 9

GO Term	Evidence	Assigned by
AU-rich element binding	Inferred from Direct Assay (IDA)	UniProtKB
double-stranded RNA binding	Inferred from Direct Assay (IDA)	MGI
miRNA binding	Inferred from Direct Assay (IDA)	UniProtKB
mRNA 3'-UTR AU-rich region binding	Inferred from Direct Assay (IDA)	UniProtKB
mRNA 3'-UTR binding	Inferred from Direct Assay (IDA)	UniProtKB
RNA binding	Inferred from Direct Assay (IDA)	UniProtKB
protein homodimerization activity	Inferred from Physical Interaction (IPI)	UniProtKB
protein kinase binding	Inferred from Physical Interaction (IPI)	UniProtKB
mRNA binding	Traceable Author Statement (TAS)	ProtInc

GWAS Traits (7)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
type II diabetes mellitus	EFO_0001360	4	3	2	1	86.8
CCL25 measurement	EFO_0010768	1	1	1		81.9
viral load	EFO_0010125	1	1	1		71.6
sex hormone-binding globulin measurement	EFO_0004696	4	1	4		67.3
high density lipoprotein cholesterol measurement	EFO_0004612	1	1	1		45.7

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
type II diabetes mellitus	EFO_0001360	2	1	86.8
CCL25 measurement	EFO_0010768	1		81.9
viral load	EFO_0010125	1		71.6
sex hormone-binding globulin measurement	EFO_0004696	4		67.3
high density lipoprotein cholesterol measurement	EFO_0004612	1		45.7

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Isopeptide bond
Methylation
Nucleus
Phosphoprotein
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
appendicular lean mass
CCL25 measurement
high density lipoprotein cholesterol measurement
sex hormone-binding globulin measurement
testosterone measurement
type II diabetes mellitus
viral load

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
cellular phenotype
craniofacial phenotype
digestive/alimentary phenotype
embryo phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	ELAV like RNA binding protein 1		743010
Macaque	ELAV like RNA binding protein 1		705806
Mouse	ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R)	MGI:1100851	15568
Rat	ELAV like RNA binding protein 1	RGD:1308649	363854
Dog	ELAV like RNA binding protein 1		611201

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ELAV like RNA binding protein 1
Macaque	ELAV like RNA binding protein 1
Mouse	ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R)
Rat	ELAV like RNA binding protein 1
Dog	ELAV like RNA binding protein 1

Publication Statistics

PubMed Score 1049.58

PubMed score by year

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PubTator Score 507.00

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