Protein Summary
RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462). Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:8626503, PubMed:17632515, PubMed:18285462, PubMed:23519412, PubMed:14731398). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZN ...more
- ENST00000407627
- ENSP00000385269
- ENSG00000066044
- ENST00000596459
- ENSP00000472197
- HUR
- HUR
- Hua
- MelG
- ELAV1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 1 | ||
interacting protein | 1 | ||
protein complex | 0.99 | ||
hub protein | 0.95 | ||
biological term | 0.93 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 663.26 (req: < 5)
Gene RIFs: 356 (req: <= 3)
Antibodies: 433 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 663.26 (req: >= 5)
Gene RIFs: 356 (req: > 3)
Antibodies: 433 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 3
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (3)
1 – 3 of 3
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
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PDB Structure Id | M.W. | Resolution | Pub Year |
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Pathways (22)
Reactome (6)
KEGG (2)
PathwayCommons (1)
WikiPathways (13)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 6
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | HuR (ELAVL1) binds and stabilizes mRNA | ||||
Reactome | Metabolism of RNA | ||||
Reactome | Processing of Capped Intron-Containing Pre-mRNA | ||||
Reactome | Regulation of mRNA stability by proteins that bind AU-rich elements | ||||
Reactome | mRNA Splicing | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
HuR (ELAVL1) binds and stabilizes mRNA | ||||
Metabolism of RNA | ||||
Processing of Capped Intron-Containing Pre-mRNA | ||||
Regulation of mRNA stability by proteins that bind AU-rich elements | ||||
mRNA Splicing | ||||
Gene Ontology Terms (27)
Functions (9)
Components (9)
Processes (9)
Items per page:
10
1 – 9 of 9
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Protein-Protein Interactions (500)
1 – 10 of 500
PTBP1
Novelty: 0.00204645
Score: 0.999
Data Source: STRINGDB
HNRNPK
Novelty: 0.00343899
Score: 0.998
Data Source: STRINGDB
CDC5L
Family: TF
Novelty: 0.00617757
Score: 0.998
Data Source: STRINGDB
HNRNPC
Novelty: 0.00195495
Score: 0.998
Data Source: STRINGDB
SRSF1
Novelty: 0.00119334
Score: 0.997
Data Source: STRINGDB
HNRNPH1
Novelty: 0.01807307
Score: 0.997
Data Source: STRINGDB
TRA2B
Novelty: 0.02179789
Score: 0.997
Data Source: STRINGDB
HNRNPA2B1
Novelty: 0.00503583
Score: 0.997
Data Source: STRINGDB
HNRNPA1
Novelty: 0.00262355
Score: 0.997
Data Source: STRINGDB
SRSF3
Novelty: 0.0126411
Score: 0.997
Data Source: STRINGDB
Publication Statistics
PubMed Score 663.26
PubMed score by year
PubTator Score 507
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MSNGYEDHMAEDCRGDIGRTNLIVNYLPQNMTQDELRSLFSSIGEVESAKLIRDKVAGHSLGYGFVNYVT
1-70
AKDAERAINTLNGLRLQSKTIKVSYARPSSEVIKDANLYISGLPRTMTQKDVEDMFSRFGRIINSRVLVD
70-140
QTTGLSRGVAFIRFDKRSEAEEAITSFNGHKPPGSSEPITVKFAANPNQNKNVALLSQLYHSPARRFGGP
140-210
VHHQAQRFRFSPMGVDHMSGLSGVNVPGNASSGWCIFIYNLGQDADEGILWQMFGPFGAVTNVKVIRDFN
210-280
TNKCKGFGFVTMTNYEEAAMAIASLNGYRLGDKILQVSFKTNKSHK
280-326
MSNGYEDHMAEDCRGDIGRTNLIVNYLPQNMTQDELRSLFSSIGEVESAKLIRDKVAGHSLGYGFVNYVTAKDAERAINTLNGLRLQSKTIKVSYARPSSEVIKDANLYISGLPRTMTQKDVEDMFSRFGRIINSRVLVDQTTGLSRGVAFIRFDKRSEAEEAITSFNGHKPPGSSEPITVKFAANPNQNKNVALLSQLYHSPARRFGGPVHHQAQRFRFSPMGVDHMSGLSGVNVPGNASSGWCIFIYNLGQDADEGILWQMFGPFGAVTNVKVIRDFNTNKCKGFGFVTMTNYEEAAMAIASLNGYRLGDKILQVSFKTNKSHK
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