Tchem ELAVL1 ELAV-like protein 1

Protein Summary

Description

RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462). Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:8626503, PubMed:17632515, PubMed:18285462, PubMed:23519412, PubMed:14731398). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR (PubMed:29180010). The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. [provided by RefSeq, Sep 2012]

Uniprot Accession IDs

• Q15717
• B4DVB8
• Q53XN6
• Q9BTT1

Gene Name

• ELAVL1

Ensembl ID

• ENST00000407627
• ENSP00000385269
• ENSG00000066044
• ENST00000596459
• ENSP00000472197

Symbol

• HUR
• HUR
• Hua
• MelG
• ELAV1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
interacting protein	1
protein complex	0.99
hub protein	0.95
biological term	0.93

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 663.26   (req: < 5)

Gene RIFs: 356   (req: <= 3)

Antibodies: 433   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 663.26   (req: >= 5)

Gene RIFs: 356   (req: > 3)

Antibodies: 433   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (3)

Explore Active Ligands

1 – 3 of 3

CHEMBL1242196

ELAVL1Tchem

Kd: 11

CHEMBL1240928

ELAVL1Tchem

Kd: 10

CHEMBL1240971

ELAVL1Tchem

Kd: 7.07

Protein Data Bank (5)

1 – 5 of 5

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (22)

Reactome (6)

KEGG (2)

PathwayCommons (1)

WikiPathways (13)

HuR (ELAVL1) binds and stabilizes mRNA (R-HSA-450520)

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Items per page:

5

1 – 5 of 6

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	HuR (ELAVL1) binds and stabilizes mRNA	10 targets	R-HSA-450520
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
Reactome	Regulation of mRNA stability by proteins that bind AU-rich elements	90 targets	R-HSA-450531
Reactome	mRNA Splicing	188 targets	R-HSA-72172

Name	Explore in Pharos	Explore in Source
HuR (ELAVL1) binds and stabilizes mRNA	10 targets	R-HSA-450520
Metabolism of RNA	686 targets	R-HSA-8953854
Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
Regulation of mRNA stability by proteins that bind AU-rich elements	90 targets	R-HSA-450531
mRNA Splicing	188 targets	R-HSA-72172

Gene Ontology Terms (27)

Functions (9)

Components (9)

Processes (9)

Items per page:

10

1 – 9 of 9

GO Term	Evidence	Assigned by
AU-rich element binding	Inferred from Direct Assay (IDA)	UniProtKB
double-stranded RNA binding	Inferred from Direct Assay (IDA)	MGI
miRNA binding	Inferred from Direct Assay (IDA)	UniProtKB
mRNA 3'-UTR AU-rich region binding	Inferred from Direct Assay (IDA)	UniProtKB
mRNA 3'-UTR binding	Inferred from Direct Assay (IDA)	UniProtKB
RNA binding	Inferred from Direct Assay (IDA)	UniProtKB
protein homodimerization activity	Inferred from Physical Interaction (IPI)	UniProtKB
protein kinase binding	Inferred from Physical Interaction (IPI)	UniProtKB
mRNA binding	Traceable Author Statement (TAS)	ProtInc

Protein-Protein Interactions (500)

Explore Interacting Targets

1 – 10 of 500

• See Interactions on String-DB

PTBP1

Tbio

Novelty: 0.00204645

Score: 0.999

Data Source: STRINGDB

HNRNPK

Tbio

Novelty: 0.00343899

Score: 0.998

Data Source: STRINGDB

CDC5L

Tbio

Family: TF

Novelty: 0.00617757

Score: 0.998

Data Source: STRINGDB

HNRNPC

Tbio

Novelty: 0.00195495

Score: 0.998

Data Source: STRINGDB

SRSF1

Tbio

Novelty: 0.00119334

Score: 0.997

Data Source: STRINGDB

HNRNPH1

Tbio

Novelty: 0.01807307

Score: 0.997

Data Source: STRINGDB

TRA2B

Tbio

Novelty: 0.02179789

Score: 0.997

Data Source: STRINGDB

HNRNPA2B1

Tbio

Novelty: 0.00503583

Score: 0.997

Data Source: STRINGDB

HNRNPA1

Tchem

Novelty: 0.00262355

Score: 0.997

Data Source: STRINGDB

SRSF3

Tbio

Novelty: 0.0126411

Score: 0.997

Data Source: STRINGDB

Publication Statistics

PubMed Score  663.26

PubMed score by year

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PubTator Score  507

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MSNGYEDHMAEDCRGDIGRTNLIVNYLPQNMTQDELRSLFSSIGEVESAKLIRDKVAGHSLGYGFVNYVT

1-70

AKDAERAINTLNGLRLQSKTIKVSYARPSSEVIKDANLYISGLPRTMTQKDVEDMFSRFGRIINSRVLVD

70-140

QTTGLSRGVAFIRFDKRSEAEEAITSFNGHKPPGSSEPITVKFAANPNQNKNVALLSQLYHSPARRFGGP

140-210

VHHQAQRFRFSPMGVDHMSGLSGVNVPGNASSGWCIFIYNLGQDADEGILWQMFGPFGAVTNVKVIRDFN

210-280

TNKCKGFGFVTMTNYEEAAMAIASLNGYRLGDKILQVSFKTNKSHK

280-326

MSNGYEDHMAEDCRGDIGRTNLIVNYLPQNMTQDELRSLFSSIGEVESAKLIRDKVAGHSLGYGFVNYVTAKDAERAINTLNGLRLQSKTIKVSYARPSSEVIKDANLYISGLPRTMTQKDVEDMFSRFGRIINSRVLVDQTTGLSRGVAFIRFDKRSEAEEAITSFNGHKPPGSSEPITVKFAANPNQNKNVALLSQLYHSPARRFGGPVHHQAQRFRFSPMGVDHMSGLSGVNVPGNASSGWCIFIYNLGQDADEGILWQMFGPFGAVTNVKVIRDFNTNKCKGFGFVTMTNYEEAAMAIASLNGYRLGDKILQVSFKTNKSHK

Find similar targets by:

Uniprot Keyword

3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Isopeptide bond
Methylation
Nucleus
Phosphoprotein
Reference proteome