Protein Summary
RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462). Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:8626503, PubMed:17632515, PubMed:18285462, PubMed:23519412, PubMed:14731398). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZN ...more
- ENST00000407627
- ENSP00000385269
- ENSG00000066044
- ENST00000596459
- ENSP00000472197
- HUR
- HUR
- Hua
- MelG
- ELAV1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
interacting protein | 1 | ||
protein complex | 0.99 | ||
hub protein | 0.95 | ||
biological term | 0.93 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1012.46 (req: < 5)
Gene RIFs: 356 (req: <= 3)
Antibodies: 433 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1012.46 (req: >= 5)
Gene RIFs: 356 (req: > 3)
Antibodies: 433 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 3
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (3)
1 – 3 of 3
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ELAV like RNA binding protein 1 | 743010 | ||||||
Macaque | ELAV like RNA binding protein 1 | 705806 | ||||||
Mouse | MGI:1100851 | 15568 | ||||||
Rat | RGD:1308649 | 363854 | ||||||
Dog | ELAV like RNA binding protein 1 | 611201 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ELAV like RNA binding protein 1 | |||||
Macaque | ELAV like RNA binding protein 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | ELAV like RNA binding protein 1 | |||||
Protein Structure (5 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 5
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (22)
Reactome (6)
KEGG (2)
PathwayCommons (1)
WikiPathways (13)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 6
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | HuR (ELAVL1) binds and stabilizes mRNA | ||||
Reactome | Metabolism of RNA | ||||
Reactome | Processing of Capped Intron-Containing Pre-mRNA | ||||
Reactome | Regulation of mRNA stability by proteins that bind AU-rich elements | ||||
Reactome | mRNA Splicing | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
HuR (ELAVL1) binds and stabilizes mRNA | ||||
Metabolism of RNA | ||||
Processing of Capped Intron-Containing Pre-mRNA | ||||
Regulation of mRNA stability by proteins that bind AU-rich elements | ||||
mRNA Splicing | ||||
Gene Ontology Terms (27)
Functions (9)
Components (9)
Processes (9)
Items per page:
10
1 – 9 of 9
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Protein-Protein Interactions (500)
1 – 10 of 500
PTBP1
Novelty: 0.00184728
Score: 0.999
Data Source: STRINGDB
HNRNPK
Novelty: 0.00354731
Score: 0.998
Data Source: STRINGDB
CDC5L
Family: TF
Novelty: 0.00663599
Score: 0.998
Data Source: STRINGDB
HNRNPC
Novelty: 0.00136097
Score: 0.998
Data Source: STRINGDB
SRSF1
Novelty: 0.00074446
Score: 0.997
Data Source: STRINGDB
HNRNPH1
Novelty: 0.01273351
Score: 0.997
Data Source: STRINGDB
TRA2B
Novelty: 0.0146833
Score: 0.997
Data Source: STRINGDB
HNRNPA2B1
Novelty: 0.00404935
Score: 0.997
Data Source: STRINGDB
HNRNPA1
Novelty: 0.0020871
Score: 0.997
Data Source: STRINGDB
SRSF3
Novelty: 0.01015895
Score: 0.997
Data Source: STRINGDB
Publication Statistics
PubMed Score 1012.46
PubMed score by year
PubTator Score 507
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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