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Tbio
ZNF174
Zinc finger protein 174

Protein Summary
Description
Transcriptional repressor. This gene encodes a protein with three Cys2-His2-type zinc fingers in the carboxy-terminus, a putative nuclear localization signal, and an amino-terminus SCAN box which forms homodimers. This protein is believed to function as a transcriptional repressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268655
  • ENSP00000268655
  • ENSG00000103343
  • ENST00000344823
  • ENSP00000339781
  • ENST00000571936
  • ENSP00000460397
  • ENST00000575752
  • ENSP00000461502

Symbol
  • ZSCAN8
  • ZSCAN8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
histone modification site profile
0.87
molecular function
0.67
transcription factor binding site profile
0.67
tissue sample
0.65


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.28   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 201   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.28   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 174
VGNC:5960
453863
Macaque
zinc finger protein 174
702964
Mouse
MGI:2686600
385674
Rat
RGD:7498198
102551846
Dog
zinc finger protein 174
VGNC:48666
490035
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 174
Macaque
zinc finger protein 174
Mouse
Rat
Dog
zinc finger protein 174
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15697-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (14)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred by Curator (IC)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (32)
1 – 10 of 32
ZSCAN20
Tdark
Family: TF
Novelty: 0.37441538
p_int: 0.999999423
p_ni: 5.76e-7
p_wrong: 1e-9
Score: 0.775
Data Source: BioPlex,STRINGDB
ZNF397
Tbio
Family: TF
Novelty: 0.60034816
p_int: 0.999998554
p_ni: 0.000001326
p_wrong: 1.2e-7
Score: 0.812
Data Source: BioPlex,STRINGDB
ZSCAN1
Tbio
Family: TF
Novelty: 0.0217244
p_int: 0.999997998
p_ni: 0.000002002
Score: 0.694
Data Source: BioPlex,STRINGDB
ZNF396
Tbio
Family: TF
Novelty: 0.95895478
p_int: 0.999995079
p_ni: 0.000004917
p_wrong: 4e-9
Score: 0.827
Data Source: BioPlex,STRINGDB
ZSCAN32
Tdark
Family: TF
Novelty: 3.83392226
p_int: 0.999991801
p_ni: 0.000008196
p_wrong: 4e-9
Score: 0.828
Data Source: BioPlex,STRINGDB
ZNF232
Tdark
Family: TF
Novelty: 0.68288358
p_int: 0.999980709
p_ni: 0.000008191
p_wrong: 0.0000111
Score: 0.704
Data Source: BioPlex,STRINGDB
ZKSCAN8
Tbio
Family: TF
Novelty: 0.17881042
p_int: 0.999943573
p_ni: 0.000055466
p_wrong: 9.61e-7
Score: 0.326
Data Source: BioPlex,STRINGDB
ZNF213
Tdark
Family: TF
Novelty: 0.24190639
p_int: 0.999932634
p_ni: 0.000057264
p_wrong: 0.000010102
Score: 0.193
Data Source: BioPlex,STRINGDB
PGBD1
Tbio
Novelty: 0.10454627
p_int: 0.999928553
p_ni: 0.000020257
p_wrong: 0.00005119
Score: 0.823
Data Source: BioPlex,STRINGDB
ZKSCAN4
Tbio
Family: TF
Novelty: 0.33154485
p_int: 0.999926269
p_ni: 0.000073613
p_wrong: 1.18e-7
Score: 0.834
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  19.28

PubMed score by year
PubTator Score  9.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer