Tbio ZRSR2 U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2

Protein Summary

Description

Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing. This gene encodes an essential splicing factor. The encoded protein associates with the U2 auxiliary factor heterodimer, which is required for the recognition of a functional 3' splice site in pre-mRNA splicing, and may play a role in network interactions during spliceosome assembly. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q15696
• Q14D69

Gene Name

• ZRSR2

Ensembl ID

• ENST00000307771
• ENSP00000303015
• ENSG00000169249

Symbol

• U2AF1-RS2
• U2AF1L2
• U2AF1RS2
• URP
• URP
• ZC3H22
• U2AF1L2
• U2AF1RS2
• U2AF1-RS2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.95
disease perturbation	0.93
histone modification site profile	0.9
kinase perturbation	0.71
tissue sample	0.71

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribonucleoprotein / U2 Small Nuclear Ribonucleoprotein Auxiliary Factor 35 Kda Subunit-related Protein 2

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribonucleoprotein / U2 Small Nuclear Ribonucleoprotein Auxiliary Factor 35 Kda Subunit-related Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.1   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 103   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.1   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0