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Tbio
ZRSR2
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2

Protein Summary
Description
Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing. This gene encodes an essential splicing factor. The encoded protein associates with the U2 auxiliary factor heterodimer, which is required for the recognition of a functional 3' splice site in pre-mRNA splicing, and may play a role in network interactions during spliceosome assembly. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307771
  • ENSP00000303015
  • ENSG00000169249

Symbol
  • U2AF1-RS2
  • U2AF1L2
  • U2AF1RS2
  • URP
  • URP
  • ZC3H22
  • U2AF1L2
  • U2AF1RS2
  • U2AF1-RS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.95
disease perturbation
0.93
histone modification site profile
0.9
kinase perturbation
0.71
tissue sample
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.32   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 103   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.32   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Minor Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Minor Pathway
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (142)
1 – 10 of 142
ZRSR2P1
Tdark
Novelty: 0.0419972
p_int: 0.999999997
p_ni: 1e-9
p_wrong: 2e-9
Score: 0.912
Data Source: BioPlex,STRINGDB
ZCRB1
Tdark
Novelty: 0.37037037
p_int: 0.99999995
p_ni: 5e-8
Score: 0.957
Data Source: BioPlex,STRINGDB
PHF5A
Tbio
Family: Epigenetic
Novelty: 0.00307327
p_int: 0.999999935
p_ni: 6.4e-8
p_wrong: 1e-9
Score: 0.919
Data Source: BioPlex,STRINGDB
SNRPN
Tbio
Novelty: 0.00241221
p_int: 0.999999688
p_ni: 3.11e-7
p_wrong: 1e-9
Score: 0.342
Data Source: BioPlex,STRINGDB
SNRNP35
Tdark
Novelty: 3
p_int: 0.999999007
p_ni: 9.89e-7
p_wrong: 3e-9
Score: 0.984
Data Source: BioPlex,STRINGDB
RNPC3
Tbio
Novelty: 0.15117801
p_int: 0.999997498
p_ni: 0.000002501
Score: 0.993
Data Source: BioPlex,STRINGDB
SNRPGP15
Tdark
p_int: 0.999995677
p_ni: 0.000004323
Data Source: BioPlex
SNRNP48
Tbio
Novelty: 0.19354839
p_int: 0.999993744
p_ni: 0.000006255
p_wrong: 1e-9
Score: 0.981
Data Source: BioPlex,STRINGDB
PDCD7
Tbio
Novelty: 0.03838488
p_int: 0.999991304
p_ni: 0.000008696
Score: 0.979
Data Source: BioPlex,STRINGDB
SNRPE
Tbio
Novelty: 0.00150118
p_int: 0.999989493
p_ni: 0.000010507
Score: 0.951
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  11.32

PubMed score by year
PubTator Score  13.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer