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Tbio
MAPRE1
Microtubule-associated protein RP/EB family member 1

Protein Summary
Description
Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:28726242, PubMed:28814570). Promotes cytoplasmic microtubule nucleation and elongation (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:28726242, PubMed:28814570). May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes (PubMed:12388762). Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). Acts as a regulator of autophagosome transport via interact ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375571
  • ENSP00000364721
  • ENSG00000101367

Symbol
  • EB1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
transcription factor perturbation
0.98
kinase perturbation
0.96
co-expressed gene
0.87
disease perturbation
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.84   (req: < 5)
Gene RIFs: 62   (req: <= 3)
Antibodies: 253   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.84   (req: >= 5)
Gene RIFs: 62   (req: > 3)
Antibodies: 253   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
49.6
mean platelet volume
1
1
1
27
cup-to-disc ratio measurement
1
1
1
25.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
49.6
mean platelet volume
1
27
cup-to-disc ratio measurement
1
25.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
microtubule associated protein RP/EB family member 1
VGNC:14259
746655
Mouse
MGI:891995
13589
Rat
RGD:621781
114764
Dog
microtubule associated protein RP/EB family member 1
100685707
Horse
microtubule associated protein RP/EB family member 1
VGNC:19970
100053947
Species
Name
OMA
EggNOG
Inparanoid
Chimp
microtubule associated protein RP/EB family member 1
Mouse
Rat
Dog
microtubule associated protein RP/EB family member 1
Horse
microtubule associated protein RP/EB family member 1
Protein Structure (27 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15691-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 27
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (32)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 29
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Anchoring of the basal body to the plasma membrane
Cell Cycle
Gene Ontology Terms (33)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (323)
1 – 10 of 323
DST
Tbio
Novelty: 0.00238839
p_int: 0.999999999
p_ni: 1e-9
Score: 0.98
Data Source: BioPlex,STRINGDB
MAPRE3
Tbio
Novelty: 0.00454315
p_int: 0.999999996
p_ni: 4e-9
Score: 0.992
Data Source: BioPlex,STRINGDB
CLASP2
Tbio
Novelty: 0.0353308
p_int: 0.999997957
p_ni: 0.000002043
Score: 0.965
Data Source: BioPlex,STRINGDB
MAPRE2
Tbio
Novelty: 0.00692773
p_int: 0.999996065
p_ni: 0.000003935
Score: 0.721
Data Source: BioPlex,STRINGDB
PDE4DIP
Tbio
Novelty: 0.03414104
p_int: 0.999991863
p_ni: 0.000008137
Score: 0.461
Data Source: BioPlex,STRINGDB
KIF18B
Tbio
Novelty: 0.06496349
p_int: 0.99998215
p_ni: 0.00001785
Score: 0.625
Data Source: BioPlex,STRINGDB
PPP1R13L
Tbio
Novelty: 0.01378765
p_int: 0.999965789
p_ni: 0.000034211
Score: 0.232
Data Source: BioPlex,STRINGDB
GAS2L1
Tbio
Novelty: 0.17484834
p_int: 0.998933349
p_ni: 0.001066651
Score: 0.71
Data Source: BioPlex,STRINGDB
MACF1
Tbio
Novelty: 0.0166336
p_int: 0.995075311
p_ni: 0.004924689
Score: 0.926
Data Source: BioPlex,STRINGDB
AKAP9
Tbio
Family: Enzyme
Novelty: 0.0106532
p_int: 0.976008411
p_ni: 0.023991589
Score: 0.979
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  60.84

PubMed score by year
PubTator Score  277.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer