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Tbio
RHOH
Rho-related GTP-binding protein RhoH

Protein Summary
Description
Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and activation of ZAP70. Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways. Essential for efficient beta-selection and positive selection by promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signaling. Crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection. Plays critical roles in mast cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Essential for the phosphorylation of LAT, LCP2, PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells (By similarity). Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. Inhibits the activation ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381799
  • ENSP00000371219
  • ENSG00000168421
  • ENST00000505618
  • ENSP00000425010
  • ENST00000610353
  • ENSP00000480192
  • ENST00000613272
  • ENSP00000480772
  • ENST00000614836
  • ENSP00000478248
  • ENST00000615083
  • ENSP00000480379
  • ENST00000615577
  • ENSP00000481566
  • ENST00000617441
  • ENSP00000482947
  • ENST00000619474
  • ENSP00000481746
  • ENST00000622175
  • ENSP00000481836

Symbol
  • ARHH
  • TTF
  • TTF
  • ARHH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.97
PubMedID
0.81
kinase perturbation
0.71
transcription factor
0.65
tissue
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.84   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 227   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.84   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HIV-1 infection
1
1
1
58
viral load
1
1
1
58
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HIV-1 infection
1
58
viral load
1
58
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ras homolog family member H
700499
Mouse
MGI:1921984
74734
Rat
RGD:1307623
305341
Dog
ras homolog family member H
VGNC:45561
488833
Horse
ras homolog family member H
VGNC:22378
100054984
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ras homolog family member H
Mouse
Rat
Dog
ras homolog family member H
Horse
ras homolog family member H
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q15669-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (34)
Rho GTPase cycle (R-HSA-194840)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Gene Ontology Terms (22)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (218)
1 – 10 of 218
ARHGDIA
Tchem
Novelty: 0.001991
Score: 0.976
Data Source: STRINGDB
VAV1
Tchem
Novelty: 0.00180518
Score: 0.971
Data Source: STRINGDB
ARHGDIB
Tbio
Novelty: 0.01139758
Score: 0.967
Data Source: STRINGDB
MCF2
Tbio
Novelty: 0.00345951
Score: 0.967
Data Source: STRINGDB
ITSN1
Tbio
Novelty: 0.01327346
Score: 0.964
Data Source: STRINGDB
ARHGAP35
Tbio
Family: Enzyme
Novelty: 0.00970784
Score: 0.962
Data Source: STRINGDB
TIAM1
Tbio
Novelty: 0.00431726
Score: 0.961
Data Source: STRINGDB
VAV2
Tbio
Novelty: 0.01062502
Score: 0.959
Data Source: STRINGDB
VAV3
Tbio
Novelty: 0.010944
Score: 0.958
Data Source: STRINGDB
ARHGAP5
Tbio
Family: Enzyme
Novelty: 0.03683127
Score: 0.956
Data Source: STRINGDB
Publication Statistics
PubMed Score  107.84

PubMed score by year
PubTator Score  330.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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