Tclin TPSAB1 Tryptase alpha/beta-1

Protein Summary

Description

Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates (PubMed:18854315). Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q15661
• D2E6R9
• D2E6S1
• P15157
• Q15663
• Q6B052
• Q9H2Y4
• Q9H2Y5
• Q9UQI1
• Tryptase-1

Gene Name

• TPSAB1

Ensembl ID

• ENST00000338844
• ENSP00000343577
• ENSG00000172236

Symbol

• TPS1
• TPS2
• TPSB1
• TPS1
• TPS2
• TPSB1
• TPSB2
• Tryptase-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Peptide Hormone / Tryptase Alpha/beta-1

Protein / Receptor / Tryptase Alpha/beta-1

Protein / Enzyme Modulator / Protease Inhibitor / Tryptase Alpha/beta-1

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Tryptase Alpha/beta-1

Protein / Calcium-binding Protein / Annexin / Tryptase Alpha/beta-1

Protein / ... / Serine Protease / Tryptase Alpha/beta-1

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Tryptase Alpha/beta-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 249.65   (req: < 5)

Gene RIFs: 64   (req: <= 3)

Antibodies: 433   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 249.65   (req: >= 5)

Gene RIFs: 64   (req: > 3)

Antibodies: 433   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 168

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2