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Tclin
TPSAB1
Tryptase alpha/beta-1

Protein Classes
Protein Summary
Description
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates (PubMed:18854315). Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protei ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338844
  • ENSP00000343577
  • ENSG00000172236

Symbol
  • TPS1
  • TPS2
  • TPSB1
  • TPS1
  • TPS2
  • TPSB1
  • TPSB2
  • Tryptase-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 217.68   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 433   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 217.68   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 433   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 168
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
nafamostat
chemical structure image
gabexate
chemical structure image
Active Ligands (168)
1 – 10 of 168
CHEMBL340098
chemical structure image
CHEMBL341148
chemical structure image
CHEMBL421643,CHEMBL404190
chemical structure image
CHEMBL124809
chemical structure image
CHEMBL339703
chemical structure image
CHEMBL127185
chemical structure image
CHEMBL46809
chemical structure image
CHEMBL536972
chemical structure image
CHEMBL341083
chemical structure image
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tryptase alpha/beta-1-like
468084
Macaque
tryptase alpha/beta-1
699599
Mouse
MGI:96942
17229
Rat
RGD:3066
54271
Horse
ret proto-oncogene
100033966
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tryptase alpha/beta-1-like
Macaque
tryptase alpha/beta-1
Mouse
Rat
Horse
ret proto-oncogene
Protein Structure (14 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15661-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 14
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Activation of Matrix Metalloproteinases (R-HSA-1592389)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Matrix Metalloproteinases
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Activation of Matrix Metalloproteinases
Degradation of the extracellular matrix
Extracellular matrix organization
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (16)
1 – 10 of 16
MMP1
Tchem
Family: Enzyme
Novelty: 0.00030922
Score: 0.901
Data Source: STRINGDB
CPA3
Tchem
Family: Enzyme
Novelty: 0.01537101
Score: 0.888
Data Source: STRINGDB
TREH
Tchem
Family: Enzyme
Novelty: 0.00462386
Score: 0.679
Data Source: STRINGDB
CPA4
Tbio
Family: Enzyme
Novelty: 0.01439845
Score: 0.643
Data Source: STRINGDB
CD1A
Tbio
Novelty: 0.00090676
Score: 0.558
Data Source: STRINGDB
CTSC
Tchem
Family: Enzyme
Novelty: 0.00119917
Score: 0.54
Data Source: STRINGDB
UGP2
Tbio
Family: Enzyme
Novelty: 0.00760963
Score: 0.536
Data Source: STRINGDB
NTHL1
Tbio
Family: Enzyme
Novelty: 0.00769394
Score: 0.491
Data Source: STRINGDB
TRMT13
Tdark
Novelty: 3.91234304
Score: 0.464
Data Source: STRINGDB
C5orf22
Tdark
Novelty: 1.29325352
Score: 0.432
Data Source: STRINGDB
Publication Statistics
PubMed Score  217.68

PubMed score by year
PubTator Score  25.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer