Tbio TRIP6 Thyroid receptor-interacting protein 6

Protein Summary

Description

Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor. This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q15654
• A4D2E7
• F2ZC07
• F2ZC08
• O15170
• O15275
• Q9BTB2
• Q9BUE5
• Q9BXP3
• Q9UNT4
• TR-interacting protein 6

Gene Name

• TRIP6

Ensembl ID

• ENST00000200457
• ENSP00000200457
• ENSG00000087077
• ENST00000417475
• ENSP00000413817
• ENST00000437505
• ENSP00000410736
• ENST00000619988
• ENSP00000479865

Symbol

• OIP1
• OIP1
• OIP-1
• ZRP-1
• TRIP-6
• TRIP6i2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.87
histone modification site profile	0.81
transcription factor perturbation	0.8
biological process	0.79
hub protein	0.79

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Kinase Modulator / Thyroid Receptor-interacting Protein 6

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Thyroid Receptor-interacting Protein 6

Protein / Cell Junction Protein / Thyroid Receptor-interacting Protein 6

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Thyroid Receptor-interacting Protein 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.01   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 371   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.01   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 371   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0