JMJD1C
Probable JmjC domain-containing histone demethylation protein 2C
Protein Summary
Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). The protein encoded by this gene interacts with thyroid hormone receptors and contains a jumonji domain. It is a candidate histone demethylase and is thought to be a coactivator for key transcription factors. It plays a role in the DNA-damage response pathway by demethylating the mediator of DNA damage checkpoint 1 (MDC1) protein, and is required for the survival of acute myeloid leukemia. Mutations in this gene are associated with Rett syndrome and intellectual disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
- ENST00000399262
- ENSP00000382204
- ENSG00000171988
- ENST00000542921
- ENSP00000444682
- JHDM2C
- KIAA1380
- TRIP8
- KDM3C
- TRIP8
- TRIP-8
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.87 | ||
trait | 0.86 | ||
transcription factor | 0.86 | ||
cell type or tissue | 0.76 | ||
transcription factor binding site profile | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 40.59 (req: < 5)
Gene RIFs: 18 (req: <= 3)
Antibodies: 130 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 40.59 (req: >= 5)
Gene RIFs: 18 (req: > 3)
Antibodies: 130 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (58)
Nearest Tclin Targets
Pathways (4)
Reactome (2)
KEGG (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Factors involved in megakaryocyte development and platelet production | ||||
Reactome | Hemostasis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Factors involved in megakaryocyte development and platelet production | ||||
Hemostasis | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (6)
Components (4)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (78)
Items per page:
1 – 5 of 78
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 9 | 9 | 10 | 99.8 | |||||
testosterone measurement | 4 | 8 | 9 | 99.5 | |||||
platelet count | 8 | 9 | 7 | 5.2 | 99.3 | ||||
sex hormone-binding globulin measurement | 5 | 5 | 10 | 99.2 | |||||
alkaline phosphatase measurement | 4 | 4 | 2 | 15.9 | 98.8 | ||||
Items per page:
1 – 5 of 78
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean platelet volume | 10 | 99.8 | |||||
testosterone measurement | 9 | 99.5 | |||||
platelet count | 7 | 5.2 | 99.3 | ||||
sex hormone-binding globulin measurement | 10 | 99.2 | |||||
alkaline phosphatase measurement | 2 | 15.9 | 98.8 | ||||
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IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | jumonji domain containing 1C | VGNC:4718 | 450489 | |||||
Macaque | jumonji domain containing 1C | 697630 | ||||||
Mouse | MGI:1918614 | 108829 | ||||||
Rat | RGD:708458 | 171120 | ||||||
Dog | jumonji domain containing 1C | VGNC:42187 | 479221 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | jumonji domain containing 1C | |||||
Macaque | jumonji domain containing 1C | |||||
Mouse | ||||||
Rat | ||||||
Dog | jumonji domain containing 1C | |||||
Publication Statistics
PubMed Score 40.59
PubMed score by year
PubTator Score 23.31
PubTator score by year
Related Publications
Text Mined References (55)
GeneRif Annotations (18)
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0 of 0
PMID | Year | Title |
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