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Tbio
JMJD1C
Probable JmjC domain-containing histone demethylation protein 2C

Protein Summary
Description
Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). The protein encoded by this gene interacts with thyroid hormone receptors and contains a jumonji domain. It is a candidate histone demethylase and is thought to be a coactivator for key transcription factors. It plays a role in the DNA-damage response pathway by demethylating the mediator of DNA damage checkpoint 1 (MDC1) protein, and is required for the survival of acute myeloid leukemia. Mutations in this gene are associated with Rett syndrome and intellectual disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399262
  • ENSP00000382204
  • ENSG00000171988
  • ENST00000542921
  • ENSP00000444682

Symbol
  • JHDM2C
  • KIAA1380
  • TRIP8
  • KDM3C
  • TRIP8
  • TRIP-8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
trait
0.86
transcription factor
0.86
cell type or tissue
0.76
transcription factor binding site profile
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.84   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.84   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (59)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
5
4
8
99.8
triglyceride measurement
12
9
17
3.1
99.1
self reported educational attainment
4
4
3
6.6
98.5
mean platelet volume
9
9
10
98.4
platelet count
7
8
6
5.2
97.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
8
99.8
triglyceride measurement
17
3.1
99.1
self reported educational attainment
3
6.6
98.5
mean platelet volume
10
98.4
platelet count
6
5.2
97.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
jumonji domain containing 1C
VGNC:4718
450489
Macaque
jumonji domain containing 1C
697630
Mouse
MGI:1918614
108829
Rat
RGD:708458
171120
Dog
jumonji domain containing 1C
VGNC:42187
479221
Species
Name
OMA
EggNOG
Inparanoid
Chimp
jumonji domain containing 1C
Macaque
jumonji domain containing 1C
Mouse
Rat
Dog
jumonji domain containing 1C
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15652-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Factors involved in megakaryocyte development and platelet production (R-HSA-983231)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Factors involved in megakaryocyte development and platelet production
Hemostasis
Gene Ontology Terms (13)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (58)
1 – 10 of 58
KDM4B
Tchem
Family: Epigenetic
Novelty: 0.01615072
Score: 0.911
Data Source: STRINGDB
KDM4C
Tchem
Family: Epigenetic
Novelty: 0.01347559
Score: 0.818
Data Source: STRINGDB
KDM4A
Tchem
Family: Epigenetic
Novelty: 0.00643043
Score: 0.818
Data Source: STRINGDB
NIPBL
Tbio
Novelty: 0.00462654
Score: 0.78
Data Source: STRINGDB
TP53BP1
Tbio
Family: Epigenetic
Novelty: 0.00131256
Score: 0.739
Data Source: STRINGDB
REEP3
Tbio
Novelty: 0.19673119
Score: 0.733
Data Source: STRINGDB
MDC1
Tbio
Novelty: 0.00533097
Score: 0.673
Data Source: STRINGDB
RD3
Tbio
Novelty: 0.00651981
Score: 0.664
Data Source: STRINGDB
RNF145
Tbio
Novelty: 0.30480192
Score: 0.651
Data Source: STRINGDB
BRPF1
Tchem
Family: Epigenetic
Novelty: 0.02524021
Score: 0.646
Data Source: STRINGDB
Publication Statistics
PubMed Score  37.84

PubMed score by year
PubTator Score  23.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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