Tbio JMJD1C Probable JmjC domain-containing histone demethylation protein 2C

Protein Summary

Description

Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity). The protein encoded by this gene interacts with thyroid hormone receptors and contains a jumonji domain. It is a candidate histone demethylase and is thought to be a coactivator for key transcription factors. It plays a role in the DNA-damage response pathway by demethylating the mediator of DNA damage checkpoint 1 (MDC1) protein, and is required for the survival of acute myeloid leukemia. Mutations in this gene are associated with Rett syndrome and intellectual disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• Q15652
• A0T124
• Q5SQZ8
• Q5SQZ9
• Q5SR00
• Q7Z3E7
• Q8N3U0
• Q96KB9
• Q9P2G7

Gene Name

• JMJD1C

Ensembl ID

• ENST00000399262
• ENSP00000382204
• ENSG00000171988
• ENST00000542921
• ENSP00000444682

Symbol

• JHDM2C
• KIAA1380
• TRIP8
• KDM3C
• TRIP8
• TRIP-8

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.87
trait	0.86
transcription factor	0.86
cell type or tissue	0.76
transcription factor binding site profile	0.76

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Probable Jmjc Domain-containing Histone Demethylation Protein 2c

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.58   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 130   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.58   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0