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Tbio
TRIP4
Activating signal cointegrator 1

Protein Summary
Description
Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a role in thyroid hormone receptor and estrogen receptor transactivation (PubMed:10454579, PubMed:25219498). Also involved in androgen receptor transactivation (By similarity). Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B (PubMed:12077347). May play a role in the development of neuromuscular junction (PubMed:26924529). May play a role in late myogenic differentiation (By similarity). This gene encodes a subunit of the tetrameric nuclear activating signal cointegrator 1 (ASC-1) complex, which associates with trans ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261884
  • ENSP00000261884
  • ENSG00000103671

Symbol
  • ASC1
  • ASC-1
  • MDCDC
  • SMABF1
  • ZC2HC5
  • HsT17391
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.95
transcription factor binding site profile
0.9
disease perturbation
0.87
molecular function
0.76
virus perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.87   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 262   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.87   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (22)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (75)
1 – 10 of 75
ASCC1
Tbio
Novelty: 0.46716062
p_int: 0.99999999
p_ni: 2e-9
p_wrong: 9e-9
Score: 0.964
Data Source: BioPlex,STRINGDB
ASCC2
Tdark
Novelty: 0.32608696
p_int: 0.999999967
p_ni: 4e-9
p_wrong: 2.9e-8
Score: 0.994
Data Source: BioPlex,STRINGDB
ALKBH3
Tchem
Family: Enzyme
Novelty: 0.02946851
p_int: 0.999958215
p_ni: 0.000041198
p_wrong: 5.87e-7
Score: 0.921
Data Source: BioPlex,STRINGDB
NOG
Tbio
Novelty: 0.00131071
p_int: 0.999772914
p_ni: 0.000226038
p_wrong: 0.000001048
Data Source: BioPlex
RPS16
Tbio
Novelty: 0.00413292
p_int: 0.99617764
p_ni: 0.003816143
p_wrong: 0.000006217
Data Source: BioPlex
MED1
Tbio
Family: Enzyme
Novelty: 0.01259825
Score: 0.997
Data Source: STRINGDB
MED4
Tbio
Family: Enzyme
Novelty: 0.01983752
Score: 0.994
Data Source: STRINGDB
MED24
Tbio
Family: Enzyme
Novelty: 0.06494678
Score: 0.993
Data Source: STRINGDB
RCOR1
Tbio
Family: TF
Novelty: 0.00972564
Score: 0.993
Data Source: STRINGDB
MED13
Tbio
Family: Enzyme
Novelty: 0.03252658
Score: 0.993
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.87

PubMed score by year
PubTator Score  12.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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