Tbio TRIP4 Activating signal cointegrator 1

Protein Summary

Description

Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a role in thyroid hormone receptor and estrogen receptor transactivation (PubMed:10454579, PubMed:25219498). Also involved in androgen receptor transactivation (By similarity). Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B (PubMed:12077347). May play a role in the development of neuromuscular junction (PubMed:26924529). May play a role in late myogenic differentiation (By similarity). This gene encodes a subunit of the tetrameric nuclear activating signal cointegrator 1 (ASC-1) complex, which associates with transcriptional coactivators, nuclear receptors and basal transcription factors to facilitate nuclear receptors-mediated transcription. This protein is localized in the nucleus and contains an E1A-type zinc finger domain, which mediates interaction with transcriptional coactivators and ligand-bound nuclear receptors, such as thyroid hormone receptor and retinoid X receptor alpha, but not glucocorticoid receptor. Mutations in this gene are associated with spinal muscular atrophy with congenital bone fractures-1 (SMABF1). [provided by RefSeq, Apr 2016]

Uniprot Accession IDs

• Q15650
• B2RAS0
• Q96ED7
• Q9UKH0
• ASC-1

Gene Name

• TRIP4

Ensembl ID

• ENST00000261884
• ENSP00000261884
• ENSG00000103671

Symbol

• ASC1
• ASC-1
• MDCDC
• SMABF1
• ZC2HC5
• HsT17391

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.95
transcription factor binding site profile	0.9
disease perturbation	0.87
molecular function	0.76
virus perturbation	0.76

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Activating Signal Cointegrator 1

DTO Classes

Protein / Transcription Factor / Transcription Cofactor / Activating Signal Cointegrator 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.69   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 262   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.69   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0