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Tbio
MED1
Mediator of RNA polymerase II transcription subunit 1

Protein Summary
Description
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These fac ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300651
  • ENSP00000300651
  • ENSG00000125686
  • ENST00000394287
  • ENSP00000377828

Symbol
  • ARC205
  • CRSP1
  • CRSP200
  • DRIP205
  • DRIP230
  • PBP
  • PPARBP
  • PPARGBP
  • RB18A
  • TRAP220
  • TRIP2
  • PBP
  • CRSP1
  • RB18A
  • TRIP2
  • PPARBP
  • CRSP200
  • DRIP205
  • DRIP230
  • PPARGBP
  • TRAP220
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
molecular function
1
disease perturbation
0.97
interacting protein
0.94


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.33   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 458   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.33   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 458   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 78
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
1
1
55.4
1
1
0
1.2
37.9
refractive error measurement
1
1
0
5.5
14.9
age at onset
1
1
0
5.5
14.9
Myopia
1
1
0
5.5
14.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
55.4
0
1.2
37.9
refractive error measurement
0
5.5
14.9
age at onset
0
5.5
14.9
Myopia
0
5.5
14.9
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mediator complex subunit 1
VGNC:9369
454629
Macaque
mediator complex subunit 1
697781
Mouse
MGI:1100846
19014
Rat
RGD:1559552
497991
Dog
mediator complex subunit 1
VGNC:43117
480533
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mediator complex subunit 1
Macaque
mediator complex subunit 1
Mouse
Rat
Dog
mediator complex subunit 1
Protein Structure (41 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15648-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 41
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (32)
Activation of gene expression by SREBF (SREBP) (R-HSA-2426168)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of gene expression by SREBF (SREBP)
Reactome
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Reactome
Circadian Clock
Reactome
Developmental Biology
Reactome
ESR-mediated signaling
Name
Explore in Pharos
Explore in Source
Activation of gene expression by SREBF (SREBP)
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Circadian Clock
Developmental Biology
ESR-mediated signaling
Gene Ontology Terms (86)
Items per page:
10
1 – 10 of 22
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (251)
1 – 10 of 251
MED19
Tbio
Family: Enzyme
Novelty: 0.03926689
p_int: 1
Score: 0.999
Data Source: BioPlex,STRINGDB
CCNC
Tbio
Novelty: 0.00585842
p_int: 1
Score: 0.999
Data Source: BioPlex,STRINGDB
MED18
Tbio
Family: Enzyme
Novelty: 0.04066825
p_int: 1
Score: 0.999
Data Source: BioPlex,STRINGDB
MED7
Tbio
Family: Enzyme
Novelty: 0.04773947
p_int: 1
Score: 0.993
Data Source: BioPlex,STRINGDB
MED21
Tbio
Family: Enzyme
Novelty: 0.06996616
p_int: 1
Score: 0.987
Data Source: BioPlex,STRINGDB
MED6
Tbio
Family: Enzyme
Novelty: 0.05215086
p_int: 0.999999923
p_ni: 7.7e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
MED26
Tbio
Family: Enzyme
Novelty: 0.05663538
p_int: 0.999999839
p_ni: 1.6e-7
Score: 0.984
Data Source: BioPlex,STRINGDB
CDK8
Tchem
Family: Kinase
Novelty: 0.00508026
p_int: 0.999999829
p_ni: 1.71e-7
Score: 0.994
Data Source: BioPlex,STRINGDB
MED13
Tbio
Family: Enzyme
Novelty: 0.02090708
p_int: 0.999999554
p_ni: 4.46e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
CDK19
Tchem
Family: Kinase
Novelty: 0.03132669
p_int: 0.999999508
p_ni: 4.92e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  115.33

PubMed score by year
PubTator Score  151.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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