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Tbio
OASL
2'-5'-oligoadenylate synthase-like protein

Protein Summary
Description
Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257570
  • ENSP00000257570
  • ENSG00000135114
  • ENST00000339275
  • ENSP00000341125
  • ENST00000620239
  • ENSP00000479512

Symbol
  • TRIP14
  • OASL1
  • OASLd
  • TRIP14
  • TRIP-14
  • p59OASL
  • p59 OASL
  • p59-OASL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
molecular function
0.99
protein domain
0.85
gene perturbation
0.75
disease perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.02   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.02   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (397)
1 – 10 of 397
MX1
Tbio
Novelty:  0.00072554
Score:  0.999
Data Source:  STRINGDB
IFIT1
Tbio
Novelty:  0.00562299
Score:  0.997
Data Source:  STRINGDB
MX2
Tbio
Novelty:  0.00139073
Score:  0.997
Data Source:  STRINGDB
IRF7
Tbio
Family:  TF
Novelty:  0.0021839
Score:  0.996
Data Source:  STRINGDB
IFIT3
Tbio
Novelty:  0.00568113
Score:  0.995
Data Source:  STRINGDB
ISG15
Tbio
Novelty:  0.00203781
Score:  0.994
Data Source:  STRINGDB
IFIT2
Tbio
Novelty:  0.01023074
Score:  0.993
Data Source:  STRINGDB
RSAD2
Tbio
Novelty:  0.0056473
Score:  0.993
Data Source:  STRINGDB
IFI6
Tbio
Novelty:  0.02590679
Score:  0.991
Data Source:  STRINGDB
IFI35
Tbio
Novelty:  0.04309126
Score:  0.986
Data Source:  STRINGDB
Pathways (8)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon alpha/beta signaling
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon alpha/beta signaling
Gene Ontology Terms (18)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
GWAS Traits (61)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
22
31
47
13.8
100
serum gamma-glutamyl transferase measurement
8
20
19
6.8
99.9
low density lipoprotein cholesterol measurement
11
7
16
98.8
IGF-1 measurement
1
4
4
98.2
sex hormone-binding globulin measurement
6
4
8
98
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
47
13.8
100
serum gamma-glutamyl transferase measurement
19
6.8
99.9
low density lipoprotein cholesterol measurement
16
98.8
IGF-1 measurement
4
98.2
sex hormone-binding globulin measurement
8
98
Find similar targets by:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
2'-5'-oligoadenylate synthetase like
VGNC:8477
452317
Macaque
2'-5'-oligoadenylate synthetase like
698943
Mouse
MGI:2180849
231655
Rat
RGD:1308586
304545
Dog
2'-5'-oligoadenylate synthetase like
VGNC:44089
100685232
Species
Name
OMA
EggNOG
Inparanoid
Chimp
2'-5'-oligoadenylate synthetase like
Macaque
2'-5'-oligoadenylate synthetase like
Mouse
Rat
Dog
2'-5'-oligoadenylate synthetase like
Publication Statistics
PubMed Score 69.02
PubMed score by year
PubTator Score 28.26
PubTator score by year