You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TRIP11
Thyroid receptor-interacting protein 11

Protein Summary
Description
Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. Golgi auto-antigen; probably involved in maintaining cis-Golgi structure. This gene was identified based on the interaction of its protein product with thyroid hormone receptor beta. This protein is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and the C-terminal region binds the minus ends of microtubules; thus, the protein is thought to play a role in assembly and maintenance of the Golgi ribbon structure around the centrosome. Mutations in this gene cause achondrogenesis type IA.[provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267622
  • ENSP00000267622
  • ENSG00000100815

Symbol
  • CEV14
  • ODCD
  • ACG1A
  • CEV14
  • GMAP210
  • TRIP-11
  • TRIP230
  • GMAP-210
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
histone modification site profile
0.78
cellular component
0.71
gene perturbation
0.7
cell line
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.3   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 85   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.3   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (72)
EXOC3
Tbio
Novelty:  0.01051955
p_int:  0.999999953
p_ni:  4e-9
p_wrong:  4.2e-8
Score:  0.279
Data Source:  BioPlex,STRINGDB
BFSP2
Tbio
Novelty:  0.00206411
p_int:  0.999999922
p_ni:  7.3e-8
p_wrong:  5e-9
Score:  0.214
Data Source:  BioPlex,STRINGDB
ASB7
Tdark
Novelty:  0.21883348
p_int:  0.999999892
p_ni:  1.08e-7
Score:  0.192
Data Source:  BioPlex,STRINGDB
BRK1
Tbio
Novelty:  0.02289534
p_int:  0.999858474
p_ni:  0.000141526
Data Source:  BioPlex
DISC1
Tbio
Novelty:  0.00183442
p_int:  0.858867812
p_ni:  0.141132115
p_wrong:  7.3e-8
Data Source:  BioPlex
IFT20
Tbio
Novelty:  0.03005088
Score:  0.987
Data Source:  Reactome,STRINGDB
ARF1
Tchem
Family:  Enzyme
Novelty:  0.00208554
Score:  0.962
Data Source:  Reactome,STRINGDB
ALPP
Tbio
Family:  Enzyme
Novelty:  0.0037276
Score:  0.9
Data Source:  STRINGDB
GOLGA4
Tbio
Novelty:  0.01363253
Score:  0.809
Data Source:  STRINGDB
ARFGAP1
Tbio
Family:  Enzyme
Novelty:  0.02654081
Score:  0.794
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Cilium Assembly (R-HSA-5617833)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cilium Assembly
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Intra-Golgi traffic
Reactome
Intraflagellar transport
Reactome
Membrane Trafficking
Name
Explore in Pharos
Explore in Source
Cilium Assembly
Intra-Golgi and retrograde Golgi-to-ER traffic
Intra-Golgi traffic
Intraflagellar transport
Membrane Trafficking
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
6
7
7
5.7
98.4
BMI-adjusted waist circumference
5
6
8
74.4
BMI-adjusted hip circumference
1
3
3
72.6
forced expiratory volume
2
2
2
68.5
calcium measurement
1
1
1
59
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
7
5.7
98.4
BMI-adjusted waist circumference
8
74.4
BMI-adjusted hip circumference
3
72.6
forced expiratory volume
2
68.5
calcium measurement
1
59
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thyroid hormone receptor interactor 11
VGNC:3296
453113
Macaque
thyroid hormone receptor interactor 11
697489
Mouse
MGI:1924393
109181
Rat
RGD:1586166
314393
Dog
thyroid hormone receptor interactor 11
VGNC:51692
480228
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thyroid hormone receptor interactor 11
Macaque
thyroid hormone receptor interactor 11
Mouse
Rat
Dog
thyroid hormone receptor interactor 11
Publication Statistics
PubMed Score 44.30
PubMed score by year
PubTator Score 25.67
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title