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Tbio
TRIP10
Cdc42-interacting protein 4

Protein Summary
Description
Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313244
  • ENSP00000320117
  • ENSG00000125733
  • ENST00000313285
  • ENSP00000320493

Symbol
  • CIP4
  • STOT
  • STP
  • STP
  • CIP4
  • HSTP
  • STOT
  • TRIP-10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.85
disease perturbation
0.79
transcription factor
0.72
kinase perturbation
0.71
tissue sample
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.6   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 240   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.6   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 240   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (10)
Clathrin-mediated endocytosis (R-HSA-8856828)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Clathrin-mediated endocytosis
Reactome
Membrane Trafficking
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Clathrin-mediated endocytosis
Membrane Trafficking
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Gene Ontology Terms (21)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (219)
1 – 10 of 219
ARHGAP44
Tbio
Family: Enzyme
Novelty: 0.02469338
p_int: 0.999866369
p_ni: 0.000133631
Score: 0.579
Data Source: BioPlex,STRINGDB
SIGLEC5
Tbio
Novelty: 0.03336814
p_int: 0.970499611
p_ni: 0.029500389
Score: 0.197
Data Source: BioPlex,STRINGDB
LRRC31
Tdark
Novelty: 1.81818182
p_int: 0.93149754
p_ni: 0.068330193
p_wrong: 0.000172267
Score: 0.685
Data Source: BioPlex,STRINGDB
FAM189B
Tbio
Novelty: 0.62780269
p_int: 0.762062875
p_ni: 0.237923432
p_wrong: 0.000013693
Data Source: BioPlex
WASL
Tbio
Novelty: 0.00386851
Score: 0.998
Data Source: STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00039759
Score: 0.989
Data Source: STRINGDB
ITSN1
Tbio
Novelty: 0.01483242
Score: 0.983
Data Source: STRINGDB
FCHO1
Tbio
Novelty: 0.1096443
Score: 0.983
Data Source: STRINGDB
FCHO2
Tbio
Novelty: 0.21241004
Score: 0.983
Data Source: STRINGDB
ITSN2
Tbio
Novelty: 0.01558254
Score: 0.982
Data Source: STRINGDB
Publication Statistics
PubMed Score  85.60

PubMed score by year
PubTator Score  259.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MDWGTELWDQFEVLERHTQWGLDLLDRYVKFVKERTEVEQAYAKQLRSLVKKYLPKRPAKDDPESKFSQQ
1-70
QSFVQILQEVNDFAGQRELVAENLSVRVCLELTKYSQEMKQERKMHFQEGRRAQQQLENGFKQLENSKRK
70-140
FERDCREAEKAAQTAERLDQDINATKADVEKAKQQAHLRSHMAEESKNEYAAQLQRFNRDQAHFYFSQMP
140-210
QIFDKLQDMDERRATRLGAGYGLLSEAELEVVPIIAKCLEGMKVAANAVDPKNDSHVLIELHKSGFARPG
210-280
DVEFEDFSQPMNRAPSDSSLGTPSDGRPELRGPGRSRTKRWPFGKKNKPRPPPLSPLGGPVPSALPNGPP
280-350
SPRSGRDPLAILSEISKSVKPRLASFRSLRGSRGTVVTEDFSHLPPEQQRKRLQQQLEERSRELQKEVDQ
350-420
REALKKMKDVYEKTPQMGDPASLEPQIAETLSNIERLKLEVQKYEAWLAEAESRVLSNRGDSLSRHARPP
420-490
DPPASAPPDSSSNSASQDTKESSEEPPSEESQDTPIYTEFDEDFEEEPTSPIGHCVAIYHFEGSSEGTIS
490-560
MAEGEDLSLMEEDKGDGWTRVRRKEGGEGYVPTSYLRVTLN
560-601
MDWGTELWDQFEVLERHTQWGLDLLDRYVKFVKERTEVEQAYAKQLRSLVKKYLPKRPAKDDPESKFSQQQSFVQILQEVNDFAGQRELVAENLSVRVCLELTKYSQEMKQERKMHFQEGRRAQQQLENGFKQLENSKRKFERDCREAEKAAQTAERLDQDINATKADVEKAKQQAHLRSHMAEESKNEYAAQLQRFNRDQAHFYFSQMPQIFDKLQDMDERRATRLGAGYGLLSEAELEVVPIIAKCLEGMKVAANAVDPKNDSHVLIELHKSGFARPGDVEFEDFSQPMNRAPSDSSLGTPSDGRPELRGPGRSRTKRWPFGKKNKPRPPPLSPLGGPVPSALPNGPPSPRSGRDPLAILSEISKSVKPRLASFRSLRGSRGTVVTEDFSHLPPEQQRKRLQQQLEERSRELQKEVDQREALKKMKDVYEKTPQMGDPASLEPQIAETLSNIERLKLEVQKYEAWLAEAESRVLSNRGDSLSRHARPPDPPASAPPDSSSNSASQDTKESSEEPPSEESQDTPIYTEFDEDFEEEPTSPIGHCVAIYHFEGSSEGTISMAEGEDLSLMEEDKGDGWTRVRRKEGGEGYVPTSYLRVTLN