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Tbio
TRIP10
Cdc42-interacting protein 4

Protein Summary
Description
Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313244
  • ENSP00000320117
  • ENSG00000125733
  • ENST00000313285
  • ENSP00000320493

Symbol
  • CIP4
  • STOT
  • STP
  • STP
  • CIP4
  • HSTP
  • STOT
  • TRIP-10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.85
disease perturbation
0.79
transcription factor
0.72
kinase perturbation
0.71
tissue sample
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.41   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 240   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.41   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 240   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (219)
ARHGAP44
Tbio
Family:  Enzyme
Novelty:  0.11113234
p_int:  0.999866369
p_ni:  0.000133631
Score:  0.579
Data Source:  BioPlex,STRINGDB
SIGLEC5
Tbio
Novelty:  0.02616618
p_int:  0.970499611
p_ni:  0.029500389
Score:  0.197
Data Source:  BioPlex,STRINGDB
LRRC31
Tdark
Novelty:  0.46385091
p_int:  0.93149754
p_ni:  0.068330193
p_wrong:  0.000172267
Score:  0.685
Data Source:  BioPlex,STRINGDB
FAM189B
Tbio
Novelty:  0.21064304
p_int:  0.762062875
p_ni:  0.237923432
p_wrong:  0.000013693
Data Source:  BioPlex
WASL
Tbio
Novelty:  0.0029314
Score:  0.998
Data Source:  STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.989
Data Source:  STRINGDB
ITSN1
Tbio
Novelty:  0.01327346
Score:  0.983
Data Source:  STRINGDB
FCHO1
Tbio
Novelty:  0.10512826
Score:  0.983
Data Source:  STRINGDB
FCHO2
Tbio
Novelty:  0.12302279
Score:  0.983
Data Source:  STRINGDB
ITSN2
Tbio
Novelty:  0.03036854
Score:  0.982
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Clathrin-mediated endocytosis (R-HSA-8856828)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Clathrin-mediated endocytosis
Reactome
Membrane Trafficking
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Clathrin-mediated endocytosis
Membrane Trafficking
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
3
0
1.4
96.9
tumor necrosis factor ligand superfamily member 14 measurement
1
3
3
96.7
mean platelet volume
3
3
5
96
2
2
0
1.6
94.1
atrophic macular degeneration
2
2
0
1.8
94.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
96.9
tumor necrosis factor ligand superfamily member 14 measurement
3
96.7
mean platelet volume
5
96
0
1.6
94.1
atrophic macular degeneration
0
1.8
94.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thyroid hormone receptor interactor 10
VGNC:2214
455646
Mouse
MGI:2146901
106628
Rat
RGD:621145
116717
Dog
thyroid hormone receptor interactor 10
VGNC:47844
476726
Horse
thyroid hormone receptor interactor 10
VGNC:24529
100060571
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thyroid hormone receptor interactor 10
Mouse
Rat
Dog
thyroid hormone receptor interactor 10
Horse
thyroid hormone receptor interactor 10
Publication Statistics
PubMed Score 71.41
PubMed score by year
PubTator Score 259.13
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title