Tbio SF1 Splicing factor 1

Protein Summary

Description

Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor. This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence at the 3' splice site, together with the large subunit of U2 auxiliary factor (U2AF), and is required for the early stages of spliceosome assembly. It also plays a role in nuclear pre-mRNA retention and transcriptional repression. The encoded protein contains an N-terminal U2AF ligand motif, a central hnRNP K homology motif and quaking 2 region which bind a key branch-site adenosine within the branch point sequence, a zinc knuckles domain, and a C-terminal proline-rich domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]

Uniprot Accession IDs

• Q15637
• B7Z1Q1
• C9JJE2
• Q14818
• Q14819
• Q15913
• Q8IY00
• Q92744
• Q92745
• Q969H7
• Q9BW01
• Q9UEI0

Gene Name

• SF1

Ensembl ID

• ENST00000227503
• ENSP00000227503
• ENSG00000168066
• ENST00000334944
• ENSP00000334414
• ENST00000377387
• ENSP00000366604
• ENST00000377390
• ENSP00000366607
• ENST00000377394
• ENSP00000366611
• ENST00000433274
• ENSP00000396793

Symbol

• ZFM1
• ZNF162
• BBP
• MBBP
• ZFM1
• ZNF162
• D11S636
• ZCCHC25

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (protein) perturbation	0.96
interacting protein	0.94
transcription factor	0.93
transcription factor binding site profile	0.89
hub protein	0.82

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Splicing Factor 1

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Splicing Factor 1

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Splicing Factor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.92   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 372   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.92   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 372   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0