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Tbio
TARBP2
RISC-loading complex subunit TARBP2

Protein Summary
Description
Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR. HIV-1, the causative agent of acquire ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266987
  • ENSP00000266987
  • ENSG00000139546
  • ENST00000394357
  • ENSP00000377885
  • ENST00000456234
  • ENSP00000416077

Symbol
  • TRBP
  • LOQS
  • TRBP
  • TRBP1
  • TRBP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.91
disease perturbation
0.87
biological process
0.79
cell type or tissue
0.75
transcription factor perturbation
0.74


Related Tools
GENEVA
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.91   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 362   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.91   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 362   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TARBP2, RISC loading complex RNA binding subunit
VGNC:10411
736926
Macaque
TARBP2, RISC loading complex RNA binding subunit
703294
Mouse
MGI:103027
21357
Rat
RGD:1307375
363006
Dog
TARBP2, RISC loading complex RNA binding subunit
VGNC:47108
100684088
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TARBP2, RISC loading complex RNA binding subunit
Macaque
TARBP2, RISC loading complex RNA binding subunit
Mouse
Rat
Dog
TARBP2, RISC loading complex RNA binding subunit
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15633-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Gene Silencing by RNA (R-HSA-211000)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene Silencing by RNA
Reactome
Gene expression (Transcription)
Reactome
MicroRNA (miRNA) biogenesis
Reactome
Small interfering RNA (siRNA) biogenesis
Name
Explore in Pharos
Explore in Source
Gene Silencing by RNA
Gene expression (Transcription)
MicroRNA (miRNA) biogenesis
Small interfering RNA (siRNA) biogenesis
Gene Ontology Terms (37)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Protein-Protein Interactions (112)
1 – 10 of 112
AGO1
Tbio
Novelty: 0.00157424
p_int: 0.999915989
p_ni: 0.000084011
Score: 0.983
Data Source: BioPlex,STRINGDB
TRMT2A
Tbio
Family: Enzyme
Novelty: 0.15277091
p_int: 0.994365404
p_ni: 0.005634596
Data Source: BioPlex
HPSE2
Tbio
Family: Enzyme
Novelty: 0.00583615
p_int: 0.993215377
p_ni: 0.006784622
p_wrong: 1e-9
Data Source: BioPlex
RPP25L
Tdark
Family: Enzyme
Novelty: 1.39761189
p_int: 0.990522058
p_ni: 0.009477942
Data Source: BioPlex
AURKA
Tchem
Family: Kinase
Novelty: 0.0010868
p_int: 0.986356505
p_ni: 0.013643495
Score: 0.273
Data Source: BioPlex,STRINGDB
TRIM41
Tbio
Family: Enzyme
Novelty: 0.17238173
p_int: 0.98359813
p_ni: 0.01640187
Score: 0.157
Data Source: BioPlex,STRINGDB
PNKD
Tbio
Family: Enzyme
Novelty: 0.02456078
p_int: 0.928659765
p_ni: 0.071340234
Data Source: BioPlex
STRBP
Tbio
Novelty: 0.00919158
p_int: 0.910157866
p_ni: 0.089842134
Score: 0.272
Data Source: BioPlex,STRINGDB
CPA6
Tbio
Family: Enzyme
Novelty: 0.05034597
p_int: 0.910120432
p_ni: 0.089879567
p_wrong: 1e-9
Data Source: BioPlex
FOXD4L6
Tdark
Family: TF
Novelty: 9.78461538
p_int: 0.879802668
p_ni: 0.120197332
Data Source: BioPlex
Publication Statistics
PubMed Score  72.91

PubMed score by year
PubTator Score  248.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer