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Tbio
TSN
Translin

Protein Summary
Description
DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots. Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand. This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a cruc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389682
  • ENSP00000374332
  • ENSG00000211460
  • ENST00000536142
  • ENSP00000437728

Symbol
  • C3PO
  • RCHF1
  • TBRBP
  • TRSLN
  • BCLF-1
  • REHF-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
virus perturbation
0.9
histone modification site profile
0.88
transcription factor binding site profile
0.83
interacting protein
0.76


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 197.55   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 197.55   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
translin
VGNC:2895
459586
Macaque
translin
697313
Mouse
MGI:109263
22099
Rat
RGD:621107
60381
Dog
translin
VGNC:47907
100856243
Species
Name
OMA
EggNOG
Inparanoid
Chimp
translin
Macaque
translin
Mouse
Rat
Dog
translin
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Gene Silencing by RNA (R-HSA-211000)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene Silencing by RNA
Reactome
Gene expression (Transcription)
Reactome
Small interfering RNA (siRNA) biogenesis
Name
Explore in Pharos
Explore in Source
Gene Silencing by RNA
Gene expression (Transcription)
Small interfering RNA (siRNA) biogenesis
Gene Ontology Terms (10)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (56)
1 – 10 of 56
TSNAX
Tbio
Novelty: 0.00888891
p_int: 0.999998986
p_ni: 0.000001014
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
STRAP
Tbio
Family: Enzyme
Novelty: 0.0336013
p_int: 0.999479288
p_ni: 0.000520712
Score: 0.823
Data Source: BioPlex,STRINGDB
AGO2
Tbio
Novelty: 0.00057003
Score: 0.973
Data Source: Reactome,STRINGDB
ZBTB18
Tbio
Family: TF
Novelty: 0.03802355
Score: 0.871
Data Source: STRINGDB
SNX2
Tbio
Novelty: 0.03880384
Score: 0.832
Data Source: STRINGDB
CTPS1
Tbio
Family: Enzyme
Novelty: 0.00911596
Score: 0.829
Data Source: STRINGDB
UBA6
Tchem
Novelty: 0.05213412
Score: 0.828
Data Source: STRINGDB
TTC4
Tbio
Novelty: 0.00808711
Score: 0.818
Data Source: STRINGDB
VPS29
Tbio
Novelty: 0.01335106
Score: 0.796
Data Source: STRINGDB
AKAP4
Tbio
Family: Enzyme
Novelty: 0.00760557
Score: 0.751
Data Source: STRINGDB
Publication Statistics
PubMed Score  197.55

PubMed score by year
PubTator Score  93.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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