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Tbio
TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

Protein Summary
Description
The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced ce ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345057
  • ENSP00000341268
  • ENSG00000102871
  • ENST00000486556
  • ENSP00000462591

Symbol
  • Hs.89862
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.95
kinase perturbation
0.91
biological process
0.78
tissue
0.7
transcription factor binding site profile
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.74   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 496   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.74   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 496   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (54)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
CASP8 activity is inhibited
Reactome
Caspase activation via Death Receptors in the presence of ligand
Reactome
Caspase activation via extrinsic apoptotic signalling pathway
Reactome
Death Receptor Signalling
Name
Explore in Pharos
Explore in Source
Apoptosis
CASP8 activity is inhibited
Caspase activation via Death Receptors in the presence of ligand
Caspase activation via extrinsic apoptotic signalling pathway
Death Receptor Signalling
Gene Ontology Terms (30)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (172)
1 – 10 of 172
TNFRSF1A
Tchem
Novelty: 0.00037847
p_int: 0.999999992
p_ni: 4e-9
p_wrong: 4e-9
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
BPNT1
Tbio
Family: Enzyme
Novelty: 0.1114547
p_int: 0.995028804
p_ni: 0.000176677
p_wrong: 0.004794519
Score: 0.215
Data Source: BioPlex,STRINGDB
RIPK1
Tchem
Family: Kinase
Novelty: 0.00230565
Score: 0.999
Data Source: Reactome,STRINGDB
TNF
Tclin
Novelty: 0.00001457
Score: 0.999
Data Source: Reactome,STRINGDB
CASP8
Tchem
Family: Enzyme
Novelty: 0.00024321
Score: 0.998
Data Source: Reactome,STRINGDB
TRAF2
Tbio
Novelty: 0.00983658
Score: 0.997
Data Source: Reactome,STRINGDB
FADD
Tbio
Novelty: 0.00137968
Score: 0.996
Data Source: Reactome,STRINGDB
TNFRSF25
Tbio
Novelty: 0.0005039
Score: 0.984
Data Source: STRINGDB
BIRC2
Tchem
Novelty: 0.00199701
Score: 0.979
Data Source: Reactome,STRINGDB
TRAF1
Tbio
Novelty: 0.00526776
Score: 0.979
Data Source: STRINGDB
Publication Statistics
PubMed Score  141.74

PubMed score by year
PubTator Score  78.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer