Protein Classes
Protein Summary
Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2. The protein encoded by this gene is a positive regulator of the Wnt signaling pathway. The encoded protein is found associated with gamma tubulin at the centrosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]
- ENST00000440460
- ENSP00000394352
- ENSG00000150764
- ENST00000529225
- ENSP00000434130
- ENST00000615255
- ENSP00000480808
- CCD1
- KIAA1735
- CCD1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
virus perturbation | 0.98 | ||
transcription factor perturbation | 0.84 | ||
transcription factor | 0.79 | ||
biological process | 0.74 | ||
protein domain | 0.73 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21.71 (req: < 5)
Gene RIFs: 23 (req: <= 3)
Antibodies: 175 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21.71 (req: >= 5)
Gene RIFs: 23 (req: > 3)
Antibodies: 175 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
---|
PDB Structure Id | M.W. | Resolution | Pub Year |
---|
Pathways (1)
PathwayCommons (1)
Items per page:
1 – 1 of 1
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
PathwayCommons: netpath | Wnt | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Wnt | ||||
Gene Ontology Terms (13)
Functions (3)
Components (3)
Processes (7)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (31)
1 – 10 of 31
NDEL1
Novelty: 0.01425912
p_int: 1
Score: 0.636
Data Source: BioPlex,STRINGDB
FAM124A
Novelty: 3.33333333
p_int: 0.999999884
p_ni: 1.15e-7
p_wrong: 1e-9
Data Source: BioPlex
BRK1
Novelty: 0.03479369
p_int: 0.999998047
p_ni: 0.000001945
p_wrong: 8e-9
Data Source: BioPlex
FBLIM1
Novelty: 0.04280121
p_int: 0.999993625
p_ni: 0.000006275
p_wrong: 1e-7
Data Source: BioPlex
L3HYPDH
Family: Enzyme
Novelty: 0.33333333
p_int: 0.999971131
p_ni: 0.000028869
Score: 0.282
Data Source: BioPlex,STRINGDB
MAP3K4
Family: Kinase
Novelty: 0.02920916
Score: 0.763
Data Source: STRINGDB
DISC1
Novelty: 0.00165188
Score: 0.754
Data Source: STRINGDB
AXIN1
Novelty: 0.00280253
Score: 0.73
Data Source: STRINGDB
CDK5
Family: Kinase
Novelty: 0.00081843
Score: 0.713
Data Source: STRINGDB
DLAT
Family: Enzyme
Novelty: 0.00424045
Score: 0.712
Data Source: STRINGDB
Publication Statistics
PubMed Score 21.71
PubMed score by year
PubTator Score 28.45
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MLACLTRGNLLDVLQEGFNEQQLQAYVAWVNAQLKKRPAVKPVQDLRQDLRDGVILAYLIEIVAGEKLSG
1-70
VQLSPGNQQEMKNNVEKVLQFVASKKIRMHQTSAKDIVDGNLKSIMRLVLALAAHFKPGSSRTVNQGRDS
70-140
RAPLQSHRPHCATAVAQGAAAALADVCHDMSRSGRDVFRYRQRNSSMDEEIENPYWSVRALVQQYEGQQR
140-210
SPSESSCSSLTSPSPIHSAKSESIITQSEEKADFVIIPAEGIENRTEGTDSPLSRDWRPGSPGTYLETSW
210-280
EEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQSRLDQSMEEN
280-350
QDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDELHNQNVDLQRKLDERNRLL
350-420
GEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQS
420-490
NGFLLPTAGKGATSVSNRGTSDLQLVRDALRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKKQ
490-560
ERKVRVKSPRTQVGSEYRESWPPNSKLPHSQSSPTVSSTCTKVLYFTDRSLTPFMVNIPKRLEEVTLKDF
560-630
KAAIDREGNHRYHFKALDPEFGTVKEEIFHDDDAIPGWEGKIVAWVEEDHGEN
630-683
MLACLTRGNLLDVLQEGFNEQQLQAYVAWVNAQLKKRPAVKPVQDLRQDLRDGVILAYLIEIVAGEKLSGVQLSPGNQQEMKNNVEKVLQFVASKKIRMHQTSAKDIVDGNLKSIMRLVLALAAHFKPGSSRTVNQGRDSRAPLQSHRPHCATAVAQGAAAALADVCHDMSRSGRDVFRYRQRNSSMDEEIENPYWSVRALVQQYEGQQRSPSESSCSSLTSPSPIHSAKSESIITQSEEKADFVIIPAEGIENRTEGTDSPLSRDWRPGSPGTYLETSWEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVSNRGTSDLQLVRDALRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKKQERKVRVKSPRTQVGSEYRESWPPNSKLPHSQSSPTVSSTCTKVLYFTDRSLTPFMVNIPKRLEEVTLKDFKAAIDREGNHRYHFKALDPEFGTVKEEIFHDDDAIPGWEGKIVAWVEEDHGEN
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