Tbio DIXDC1 Dixin

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Dixin

Protein / Enzyme Modulator / Dixin

Protein Summary

Description

Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2. The protein encoded by this gene is a positive regulator of the Wnt signaling pathway. The encoded protein is found associated with gamma tubulin at the centrosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

Uniprot Accession IDs

• Q155Q3
• A1A5D8
• E9PRV4
• Q6P2J8
• Q6PIK4
• Q86SR7
• Q8IVY4
• Q96N69
• Q9C0C8

Gene Name

• DIXDC1

Ensembl ID

• ENST00000440460
• ENSP00000394352
• ENSG00000150764
• ENST00000529225
• ENSP00000434130
• ENST00000615255
• ENSP00000480808

Symbol

• CCD1
• KIAA1735
• CCD1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.98
transcription factor perturbation	0.84
transcription factor	0.79
biological process	0.74
protein domain	0.73

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.71   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 175   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.71   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 175   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (1)

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (1)

PathwayCommons (1)

Items per page:

5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
PathwayCommons: netpath	Wnt	118 targets	PathwayCommons: netpath

Name	Explore in Pharos	Explore in Source
Wnt	118 targets	PathwayCommons: netpath

Gene Ontology Terms (13)

Functions (3)

Components (3)

Processes (7)

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
gamma-tubulin binding	Inferred from Direct Assay (IDA)	UniProtKB
actin binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
protein domain specific binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (31)

Explore Interacting Targets

1 – 10 of 31

• See Interactions on String-DB

NDEL1

Tbio

Novelty: 0.01425912

p_int: 1

Score: 0.636

Data Source: BioPlex,STRINGDB

FAM124A

Tdark

Novelty: 3.33333333

p_int: 0.999999884

p_ni: 1.15e-7

p_wrong: 1e-9

Data Source: BioPlex

BRK1

Tbio

Novelty: 0.03479369

p_int: 0.999998047

p_ni: 0.000001945

p_wrong: 8e-9

Data Source: BioPlex

FBLIM1

Tbio

Novelty: 0.04280121

p_int: 0.999993625

p_ni: 0.000006275

p_wrong: 1e-7

Data Source: BioPlex

L3HYPDH

Tdark

Family: Enzyme

Novelty: 0.33333333

p_int: 0.999971131

p_ni: 0.000028869

Score: 0.282

Data Source: BioPlex,STRINGDB

MAP3K4

Tbio

Family: Kinase

Novelty: 0.02920916

Score: 0.763

Data Source: STRINGDB

DISC1

Tbio

Novelty: 0.00165188

Score: 0.754

Data Source: STRINGDB

AXIN1

Tbio

Novelty: 0.00280253

Score: 0.73

Data Source: STRINGDB

CDK5

Tchem

Family: Kinase

Novelty: 0.00081843

Score: 0.713

Data Source: STRINGDB

DLAT

Tbio

Family: Enzyme

Novelty: 0.00424045

Score: 0.712

Data Source: STRINGDB

Publication Statistics

PubMed Score  21.71

PubMed score by year

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PubTator Score  28.45

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MLACLTRGNLLDVLQEGFNEQQLQAYVAWVNAQLKKRPAVKPVQDLRQDLRDGVILAYLIEIVAGEKLSG

1-70

VQLSPGNQQEMKNNVEKVLQFVASKKIRMHQTSAKDIVDGNLKSIMRLVLALAAHFKPGSSRTVNQGRDS

70-140

RAPLQSHRPHCATAVAQGAAAALADVCHDMSRSGRDVFRYRQRNSSMDEEIENPYWSVRALVQQYEGQQR

140-210

SPSESSCSSLTSPSPIHSAKSESIITQSEEKADFVIIPAEGIENRTEGTDSPLSRDWRPGSPGTYLETSW

210-280

EEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQSRLDQSMEEN

280-350

QDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDELHNQNVDLQRKLDERNRLL

350-420

GEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQS

420-490

NGFLLPTAGKGATSVSNRGTSDLQLVRDALRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKKQ

490-560

ERKVRVKSPRTQVGSEYRESWPPNSKLPHSQSSPTVSSTCTKVLYFTDRSLTPFMVNIPKRLEEVTLKDF

560-630

KAAIDREGNHRYHFKALDPEFGTVKEEIFHDDDAIPGWEGKIVAWVEEDHGEN

630-683

MLACLTRGNLLDVLQEGFNEQQLQAYVAWVNAQLKKRPAVKPVQDLRQDLRDGVILAYLIEIVAGEKLSGVQLSPGNQQEMKNNVEKVLQFVASKKIRMHQTSAKDIVDGNLKSIMRLVLALAAHFKPGSSRTVNQGRDSRAPLQSHRPHCATAVAQGAAAALADVCHDMSRSGRDVFRYRQRNSSMDEEIENPYWSVRALVQQYEGQQRSPSESSCSSLTSPSPIHSAKSESIITQSEEKADFVIIPAEGIENRTEGTDSPLSRDWRPGSPGTYLETSWEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVSNRGTSDLQLVRDALRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKKQERKVRVKSPRTQVGSEYRESWPPNSKLPHSQSSPTVSSTCTKVLYFTDRSLTPFMVNIPKRLEEVTLKDFKAAIDREGNHRYHFKALDPEFGTVKEEIFHDDDAIPGWEGKIVAWVEEDHGEN

Find similar targets by:

Uniprot Keyword

3D-structure
Actin-binding
Alternative splicing
Cell junction
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
Developmental protein
Lipoprotein