Tbio NCOA2 Nuclear receptor coactivator 2

Protein Summary

Description

Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Uniprot Accession IDs

• Q15596
• Q14CD2
• NCoA-2

Gene Name

• NCOA2

Ensembl ID

• ENST00000452400
• ENSP00000399968
• ENSG00000140396

Symbol

• BHLHE75
• SRC2
• TIF2
• SRC2
• TIF2
• GRIP1
• KAT13C
• NCoA-2
• bHLHe75

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
ligand (protein) perturbation	0.99
molecular function	0.95
hub protein	0.92
transcription factor binding site profile	0.89

Protein Classes

PANTHER Classes

Protein / Transferase / Acetyltransferase / Nuclear Receptor Coactivator 2

Protein / Transcription Factor / Nuclear Receptor Coactivator 2

DTO Classes

Protein / Enzyme / Transferase / Acetyltransferase / Nuclear Receptor Coactivator 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 223.77   (req: < 5)

Gene RIFs: 98   (req: <= 3)

Antibodies: 271   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 223.77   (req: >= 5)

Gene RIFs: 98   (req: > 3)

Antibodies: 271   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0