Tbio TGIF1 Homeobox protein TGIF1

Protein Summary

Description

Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities. The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• Q15583
• A6NE42
• A6NLU7
• F8VZB6
• Q6ICR0
• Q8N5X9
• Q9NRS0

Gene Name

• TGIF1

Ensembl ID

• ENST00000330513
• ENSP00000327959
• ENSG00000177426
• ENST00000343820
• ENSP00000339631
• ENST00000345133
• ENSP00000343969
• ENST00000400167
• ENSP00000383031
• ENST00000401449
• ENSP00000385206
• ENST00000405385
• ENSP00000384970
• ENST00000407501
• ENSP00000384133
• ENST00000472042
• ENSP00000449501
• ENST00000548489
• ENSP00000447747
• ENST00000551541
• ENSP00000450025
• ENST00000618001
• ENSP00000483499

Symbol

• TGIF
• HPE4
• TGIF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.94
kinase perturbation	0.93
PubMedID	0.93
virus perturbation	0.92
transcription factor	0.88

Protein Classes

PANTHER Classes

Protein / ... / Homeodomain Transcription Factor / Homeobox Protein Tgif1

Protein / ... / Rna Binding Protein / Dna-directed Rna Polymerase / Homeobox Protein Tgif1

DTO Classes

Protein / Enzyme / Transferase / Nucleotidyltransferase / Polymerase / Dna-directed Rna Polymerase / Homeobox Protein Tgif1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.71   (req: < 5)

Gene RIFs: 67   (req: <= 3)

Antibodies: 341   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.71   (req: >= 5)

Gene RIFs: 67   (req: > 3)

Antibodies: 341   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0