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Tbio
TGIF1
Homeobox protein TGIF1

Protein Summary
Description
Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities. The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330513
  • ENSP00000327959
  • ENSG00000177426
  • ENST00000343820
  • ENSP00000339631
  • ENST00000345133
  • ENSP00000343969
  • ENST00000400167
  • ENSP00000383031
  • ENST00000401449
  • ENSP00000385206
  • ENST00000405385
  • ENSP00000384970
  • ENST00000407501
  • ENSP00000384133
  • ENST00000472042
  • ENSP00000449501
  • ENST00000548489
  • ENSP00000447747
  • ENST00000551541
  • ENSP00000450025
  • ENST00000618001
  • ENSP00000483499

Symbol
  • TGIF
  • HPE4
  • TGIF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
kinase perturbation
0.93
PubMedID
0.93
virus perturbation
0.92
transcription factor
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.71   (req: < 5)
Gene RIFs: 66   (req: <= 3)
Antibodies: 341   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.71   (req: >= 5)
Gene RIFs: 66   (req: > 3)
Antibodies: 341   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0