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Tbio
TGFBI
Transforming growth factor-beta-induced protein ig-h3

Protein Summary
Description
Plays a role in cell adhesion (PubMed:8024701). May play a role in cell-collagen interactions (By similarity). This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000442011
  • ENSP00000416330
  • ENSG00000120708

Symbol
  • BIGH3
  • CSD
  • CDB1
  • CDG2
  • CSD1
  • CSD2
  • CSD3
  • EBMD
  • LCD1
  • BIGH3
  • CDGG1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
transcription factor perturbation
1
virus perturbation
0.97
gene perturbation
0.96
biological term
0.94


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 690.3   (req: < 5)
Gene RIFs: 197   (req: <= 3)
Antibodies: 378   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 690.3   (req: >= 5)
Gene RIFs: 197   (req: > 3)
Antibodies: 378   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (91)
ITGA3
Tchem
Novelty:  0.00505981
Score:  0.928
Data Source:  STRINGDB
HSPG2
Tbio
Family:  Enzyme
Novelty:  0.00159541
Score:  0.924
Data Source:  STRINGDB
ITGB3
Tclin
Novelty:  0.00067255
Score:  0.922
Data Source:  STRINGDB
ITGB1
Tclin
Novelty:  0.00055626
Score:  0.921
Data Source:  STRINGDB
ITGAV
Tchem
Novelty:  0.00148589
Score:  0.919
Data Source:  STRINGDB
ITGB2
Tclin
Novelty:  0.00185859
Score:  0.912
Data Source:  STRINGDB
APP
Tchem
Novelty:  0.00008964
Score:  0.911
Data Source:  STRINGDB
ITGAM
Tbio
Novelty:  0.00017521
Score:  0.91
Data Source:  STRINGDB
APCS
Tchem
Novelty:  0.00155111
Score:  0.904
Data Source:  STRINGDB
FN1
Tchem
Novelty:  0.00003647
Score:  0.851
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Amyloid fiber formation (R-HSA-977225)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amyloid fiber formation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Amyloid fiber formation
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
insomnia measurement
2
2
0
1.1
65.7
mean platelet volume
1
1
1
29
heel bone mineral density
3
1
3
27.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
insomnia measurement
0
1.1
65.7
mean platelet volume
1
29
heel bone mineral density
3
27.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transforming growth factor beta induced
VGNC:4194
462081
Macaque
transforming growth factor beta induced
712503
Mouse
MGI:99959
21810
Rat
RGD:620017
116487
Dog
transforming growth factor beta induced
VGNC:47311
481519
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transforming growth factor beta induced
Macaque
transforming growth factor beta induced
Mouse
Rat
Dog
transforming growth factor beta induced
Publication Statistics
PubMed Score 690.30
PubMed score by year
PubTator Score 502.22
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title