TGFBI
Transforming growth factor-beta-induced protein ig-h3
Protein Summary
Plays a role in cell adhesion (PubMed:8024701). May play a role in cell-collagen interactions (By similarity). This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008]
- ENST00000442011
- ENSP00000416330
- ENSG00000120708
- BIGH3
- CSD
- CDB1
- CDG2
- CSD1
- CSD2
- CSD3
- EBMD
- LCD1
- BIGH3
- CDGG1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 1 | ||
transcription factor perturbation | 1 | ||
virus perturbation | 0.97 | ||
gene perturbation | 0.96 | ||
biological term | 0.94 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 756.81 (req: < 5)
Gene RIFs: 240 (req: <= 3)
Antibodies: 378 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 756.81 (req: >= 5)
Gene RIFs: 240 (req: > 3)
Antibodies: 378 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0