You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TAF1A
TATA box-binding protein-associated factor RNA polymerase I subunit A

Protein Summary
Description
Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. This gene encodes a subunit of the RNA polymerase I complex, Selectivity Factor I (SLI). The encoded protein is a TATA box-binding protein-associated factor that plays a role in the assembly of the RNA polymerase I preinitiation complex. Alternate splicing results in multiple transcript variants encoding multiple isoforms.[provided by RefSeq, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000350027
  • ENSP00000339976
  • ENSG00000143498
  • ENST00000352967
  • ENSP00000327072
  • ENST00000366890
  • ENSP00000355856

Symbol
  • SL1
  • RAFI48
  • TAFI48
  • MGC:17061
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.74
cellular component
0.73
cell type or tissue
0.7
disease perturbation
0.68
biological process
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.63   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 204   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.63   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
9
5
4
1.1
97.2
4
3
0
1.1
90.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
97.2
0
1.1
90.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TATA-box binding protein associated factor, RNA polymerase I subunit A
VGNC:8516
747636
Macaque
TATA-box binding protein associated factor, RNA polymerase I subunit A
704624
Mouse
MGI:109578
21339
Rat
RGD:1305698
360893
Dog
TATA-box binding protein associated factor, RNA polymerase I subunit A
VGNC:47077
608850
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TATA-box binding protein associated factor, RNA polymerase I subunit A
Macaque
TATA-box binding protein associated factor, RNA polymerase I subunit A
Mouse
Rat
Dog
TATA-box binding protein associated factor, RNA polymerase I subunit A
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q15573-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
B-WICH complex positively regulates rRNA expression (R-HSA-5250924)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
B-WICH complex positively regulates rRNA expression
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Reactome
Negative epigenetic regulation of rRNA expression
Reactome
NoRC negatively regulates rRNA expression
Name
Explore in Pharos
Explore in Source
B-WICH complex positively regulates rRNA expression
Epigenetic regulation of gene expression
Gene expression (Transcription)
Negative epigenetic regulation of rRNA expression
NoRC negatively regulates rRNA expression
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (112)
1 – 10 of 112
TAF1D
Tdark
Family:  Enzyme
Novelty:  0.26072519
p_int:  0.999963342
p_ni:  0.000036657
Score:  0.996
Data Source:  BioPlex,STRINGDB
TRIM44
Tbio
Novelty:  0.00483553
p_int:  0.999939674
p_ni:  0.000060326
Score:  0.23
Data Source:  BioPlex,STRINGDB
EPB41L3
Tbio
Novelty:  0.00915217
p_int:  0.999938713
p_ni:  0.000061277
p_wrong:  1.1e-8
Data Source:  BioPlex
EAF1
Tbio
Novelty:  0.81120425
p_int:  0.994655202
p_ni:  0.005344061
p_wrong:  7.37e-7
Score:  0.533
Data Source:  BioPlex,STRINGDB
TAF1B
Tbio
Family:  Enzyme
Novelty:  0.10174314
p_int:  0.993668392
p_ni:  0.006331357
p_wrong:  2.52e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
RBM34
Tdark
Novelty:  0.58131282
p_int:  0.984707015
p_ni:  0.015292808
p_wrong:  1.77e-7
Score:  0.342
Data Source:  BioPlex,STRINGDB
RPL14
Tbio
Novelty:  0.01600377
p_int:  0.958809244
p_ni:  0.041190749
p_wrong:  6e-9
Score:  0.536
Data Source:  BioPlex,STRINGDB
ZNF512
Tbio
Family:  TF
Novelty:  0.08783629
p_int:  0.918730907
p_ni:  0.081245628
p_wrong:  0.000023465
Score:  0.436
Data Source:  BioPlex,STRINGDB
RPL37A
Tbio
Novelty:  0.03475061
p_int:  0.909391715
p_ni:  0.090596241
p_wrong:  0.000012045
Data Source:  BioPlex
MECP2
Tchem
Family:  TF
Novelty:  0.00051767
p_int:  0.909238457
p_ni:  0.086518066
p_wrong:  0.004243477
Data Source:  BioPlex
Publication Statistics
PubMed Score  6.63

PubMed score by year
PubTator Score  88.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer