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Tbio
TAF1C
TATA box-binding protein-associated factor RNA polymerase I subunit C

Protein Summary
Description
Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3. Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alternatively spliced transcript variant ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341690
  • ENSP00000345305
  • ENSG00000103168
  • ENST00000541676
  • ENSP00000437900
  • ENST00000566732
  • ENSP00000455933
  • ENST00000567759
  • ENSP00000455265
  • ENST00000570117
  • ENSP00000455247

Symbol
  • SL1
  • TAFI95
  • TAFI110
  • MGC:39976
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.84
transcription factor binding site profile
0.79
virus perturbation
0.76
gene perturbation
0.66
histone modification site profile
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.28   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.28   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (15)
B-WICH complex positively regulates rRNA expression (R-HSA-5250924)

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Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
B-WICH complex positively regulates rRNA expression
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Reactome
Negative epigenetic regulation of rRNA expression
Reactome
NoRC negatively regulates rRNA expression
Name
Explore in Pharos
Explore in Source
B-WICH complex positively regulates rRNA expression
Epigenetic regulation of gene expression
Gene expression (Transcription)
Negative epigenetic regulation of rRNA expression
NoRC negatively regulates rRNA expression
Protein-Protein Interactions (125)
1 – 10 of 125
TAF1D
Tdark
Family: Enzyme
Novelty: 0.26072519
p_int: 0.999574357
p_ni: 0.000425642
p_wrong: 1e-9
Score: 0.994
Data Source: BioPlex,STRINGDB
TRIM44
Tbio
Novelty: 0.00483553
p_int: 0.999219205
p_ni: 0.000780793
p_wrong: 2e-9
Score: 0.169
Data Source: BioPlex,STRINGDB
TAF1B
Tbio
Family: Enzyme
Novelty: 0.10174314
p_int: 0.999029985
p_ni: 0.000970015
p_wrong: 1e-9
Score: 0.997
Data Source: BioPlex,STRINGDB
EPB41L3
Tbio
Novelty: 0.00915217
p_int: 0.998391245
p_ni: 0.001608755
Data Source: BioPlex
CCT2
Tbio
Novelty: 0.01967139
p_int: 0.990106828
p_ni: 0.009893162
p_wrong: 1.1e-8
Data Source: BioPlex
EAF1
Tbio
Novelty: 0.81120425
p_int: 0.985863924
p_ni: 0.014136076
Score: 0.632
Data Source: BioPlex,STRINGDB
FGF12
Tbio
Novelty: 0.02094849
p_int: 0.983497652
p_ni: 0.016502348
Data Source: BioPlex
PIAS4
Tbio
Family: TF
Novelty: 0.01388547
p_int: 0.982094638
p_ni: 0.017905361
Data Source: BioPlex
RPL18A
Tbio
Novelty: 0.04612948
p_int: 0.981195196
p_ni: 0.018804802
p_wrong: 3e-9
Score: 0.194
Data Source: BioPlex,STRINGDB
CCT3
Tbio
Novelty: 0.01642521
p_int: 0.979279571
p_ni: 0.02072043
Data Source: BioPlex
Publication Statistics
PubMed Score  7.28

PubMed score by year
PubTator Score  52.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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