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Tchem
TESK1
Dual specificity testis-specific protein kinase 1

Protein Summary
Description
Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity). This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and a C-terminal proline-rich domain. Its protein kinase domain is most closely related to those of the LIM motif-containing protein kinases (LIMKs). The encoded protein can phosphorylate myelin basic protein and histone in vitro. The testicular germ cell-specific expression and developmental pattern of expression of the mouse gene suggests that this gene plays an important role at and after the meiotic phase of spermatogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336395
  • ENSP00000338127
  • ENSG00000107140
  • ENST00000620767
  • ENSP00000481045
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
histone modification site profile
0.92
protein domain
0.85
disease perturbation
0.83
transcription factor binding site profile
0.66


Related Tools
Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.38   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 144   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.38   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
testis-specific kinase 1 [Source:HGNC Symbol;Acc:HGNC:11731]
Macaque
testis-specific kinase 1
697206
Mouse
MGI:1201675
21754
Rat
RGD:62059
29460
Dog
testis-specific kinase 1
100688993
Species
Name
OMA
EggNOG
Inparanoid
Chimp
testis-specific kinase 1 [Source:HGNC Symbol;Acc:HGNC:11731]
Macaque
testis-specific kinase 1
Mouse
Rat
Dog
testis-specific kinase 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q15569-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-extracellular matrix interactions
Reactome
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell-Cell communication
Cell-extracellular matrix interactions
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Gene Ontology Terms (17)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (47)
1 – 10 of 47
RABEPK
Tdark
Novelty: 0.97019495
p_int: 0.999946812
p_ni: 1.1e-8
p_wrong: 0.000053177
Data Source: BioPlex
PARVA
Tbio
Novelty: 0.02736601
Score: 0.958
Data Source: Reactome,STRINGDB
SPRY4
Tbio
Novelty: 0.01578378
Score: 0.888
Data Source: STRINGDB
CFL1
Tbio
Novelty: 0.00071544
Score: 0.829
Data Source: STRINGDB
SPRED1
Tbio
Novelty: 0.01050285
Score: 0.813
Data Source: STRINGDB
SPRY2
Tbio
Novelty: 0.00884945
Score: 0.797
Data Source: STRINGDB
RUSC2
Tbio
Novelty: 0.14691927
Score: 0.744
Data Source: STRINGDB
NEURL3
Tdark
Family: Enzyme
Novelty: 0.10984007
Score: 0.744
Data Source: STRINGDB
YWHAB
Tchem
Novelty: 0.00614093
Score: 0.707
Data Source: STRINGDB
FOXL2
Tbio
Family: TF
Novelty: 0.00224046
Score: 0.692
Data Source: STRINGDB
Publication Statistics
PubMed Score  16.38

PubMed score by year
PubTator Score  9.54

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer