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Tbio
TEAD2
Transcriptional enhancer factor TEF-4

Protein Classes
Protein Summary
Description
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311227
  • ENSP00000310701
  • ENSG00000074219
  • ENST00000377214
  • ENSP00000366419
  • ENST00000539846
  • ENSP00000437928
  • ENST00000593945
  • ENSP00000469640
  • ENST00000598810
  • ENSP00000472109
  • ENST00000601519
  • ENSP00000469672

Symbol
  • TEF4
  • ETF
  • TEF4
  • TEF-4
  • TEAD-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
histone modification site profile
0.84
hub protein
0.75
biological process
0.71
kinase perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.39   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 237   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.39   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 237   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (16)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
RUNX3 regulates YAP1-mediated transcription
Reactome
Transcriptional regulation by RUNX3
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
RUNX3 regulates YAP1-mediated transcription
Transcriptional regulation by RUNX3
Gene Ontology Terms (31)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (71)
1 – 10 of 71
TEAD4
Tbio
Family: TF
Novelty: 0.01736374
p_int: 1
Score: 0.984
Data Source: BioPlex,STRINGDB
TEAD1
Tbio
Family: TF
Novelty: 0.01917549
p_int: 0.999999985
p_wrong: 1.4e-8
Score: 0.986
Data Source: BioPlex,STRINGDB
WWTR1
Tbio
Novelty: 0.00564482
p_int: 0.999999984
p_wrong: 1.6e-8
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
YAP1
Tbio
Novelty: 0.00177068
p_int: 0.999999866
p_ni: 1.34e-7
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
UBN2
Tdark
Novelty: 0.16216216
p_int: 0.991286065
p_ni: 0.008707913
p_wrong: 0.000006022
Score: 0.187
Data Source: BioPlex,STRINGDB
HIRA
Tbio
Novelty: 0.02024297
p_int: 0.985780568
p_ni: 0.014099947
p_wrong: 0.000119485
Score: 0.195
Data Source: BioPlex,STRINGDB
SUPT16H
Tbio
Family: Enzyme
Novelty: 0.01332412
p_int: 0.978925739
p_ni: 0.021074261
Data Source: BioPlex
RFC1
Tbio
Novelty: 0.0408089
p_int: 0.911752666
p_ni: 0.088247334
Score: 0.187
Data Source: BioPlex,STRINGDB
CTGF
Tbio
Novelty: 0.00050526
Score: 0.947
Data Source: STRINGDB
TEAD3
Tbio
Family: TF
Novelty: 0.07618275
Score: 0.914
Data Source: STRINGDB
Publication Statistics
PubMed Score  26.39

PubMed score by year
PubTator Score  37.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer