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Tbio
TAF7
Transcription initiation factor TFIID subunit 7

Protein Classes
Protein Summary
Description
Functions as a component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively). The intronless gene for this transcription coactivator is located between the protocadherin beta and gamma gene clusters on chromosome 5. The protein encoded by this gene is a component of the TFIID protein complex, a complex which binds to the TATA box in class II promoters and recruits RNA polymerase II and other factors. This particular subunit interacts with the largest TFIID subunit, as well as multiple transcription activators. The protein is required for transcription by promoters targeted by RNA polymerase II. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313368
  • ENSP00000312709
  • ENSG00000178913

Symbol
  • TAF2F
  • TAFII55
  • TAF2F
  • TAFII55
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
biological process
0.94
disease perturbation
0.87
histone modification site profile
0.82
molecular function
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.1   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.1   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (23)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
HIV Infection
Reactome
HIV Life Cycle
Name
Explore in Pharos
Explore in Source
Disease
Gene expression (Transcription)
Generic Transcription Pathway
HIV Infection
HIV Life Cycle
Gene Ontology Terms (29)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (155)
1 – 10 of 155
SPATA25
Tbio
Novelty: 0.80142563
p_int: 0.999999923
p_ni: 7.7e-8
Data Source: BioPlex
TAF12
Tbio
Novelty: 0.04352637
p_int: 0.999999762
p_ni: 2.38e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
TAF8
Tbio
Novelty: 0.01056638
p_int: 0.999999159
p_ni: 8.41e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
TRAC
Tdark
p_int: 0.999982888
p_ni: 0.00001711
p_wrong: 3e-9
Data Source: BioPlex
IL20RA
Tbio
Novelty: 0.02416816
p_int: 0.991659523
p_ni: 0.008340477
Score: 0.183
Data Source: BioPlex,STRINGDB
C8A
Tbio
Novelty: 0.00429321
p_int: 0.99128154
p_ni: 0.008571334
p_wrong: 0.000147126
Data Source: BioPlex
JMJD6
Tbio
Family: Enzyme
Novelty: 0.00305479
p_int: 0.975989141
p_ni: 0.024009631
p_wrong: 0.000001227
Data Source: BioPlex
NXPH2
Tdark
Novelty: 0.65790631
p_int: 0.931079781
p_ni: 0.068920219
p_wrong: 1e-9
Score: 0.227
Data Source: BioPlex,STRINGDB
FAM153B
Tdark
Novelty: 4.34922003
p_int: 0.906429016
p_ni: 0.092106237
p_wrong: 0.001464747
Score: 0.239
Data Source: BioPlex,STRINGDB
TAF1
Tchem
Family: Kinase
Novelty: 0.00555929
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  16.10

PubMed score by year
PubTator Score  22.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer