Tbio TAF7 Transcription initiation factor TFIID subunit 7

Protein Summary

Description

Functions as a component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively). The intronless gene for this transcription coactivator is located between the protocadherin beta and gamma gene clusters on chromosome 5. The protein encoded by this gene is a component of the TFIID protein complex, a complex which binds to the TATA box in class II promoters and recruits RNA polymerase II and other factors. This particular subunit interacts with the largest TFIID subunit, as well as multiple transcription activators. The protein is required for transcription by promoters targeted by RNA polymerase II. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q15545
• B2RBV9
• Q13036

Gene Name

• TAF7

Ensembl ID

• ENST00000313368
• ENSP00000312709
• ENSG00000178913

Symbol

• TAF2F
• TAFII55
• TAF2F
• TAFII55

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.99
biological process	0.94
disease perturbation	0.87
histone modification site profile	0.82
molecular function	0.81

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.17   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 165   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.17   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

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Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Protein-Protein Interactions (155)

Explore Interacting Targets

1 – 10 of 155

• See Interactions on String-DB

SPATA25

Tbio

Novelty:  0.80142563

p_int:  0.999999923

p_ni:  7.7e-8

Data Source:  BioPlex

TAF12

Tbio

Novelty:  0.04352637

p_int:  0.999999762

p_ni:  2.38e-7

Score:  0.999

Data Source:  BioPlex,STRINGDB

TAF8

Tbio

Novelty:  0.01056638

p_int:  0.999999159

p_ni:  8.41e-7

Score:  0.999

Data Source:  BioPlex,STRINGDB

TRAC

Tdark

p_int:  0.999982888

p_ni:  0.00001711

p_wrong:  3e-9

Data Source:  BioPlex

IL20RA

Tbio

Novelty:  0.02416816

p_int:  0.991659523

p_ni:  0.008340477

Score:  0.183

Data Source:  BioPlex,STRINGDB

C8A

Tbio

Novelty:  0.00429321

p_int:  0.99128154

p_ni:  0.008571334

p_wrong:  0.000147126

Data Source:  BioPlex

JMJD6

Tchem

Family:  Enzyme

Novelty:  0.00305479

p_int:  0.975989141

p_ni:  0.024009631

p_wrong:  0.000001227

Data Source:  BioPlex

NXPH2

Tdark

Novelty:  0.65790631

p_int:  0.931079781

p_ni:  0.068920219

p_wrong:  1e-9

Score:  0.227

Data Source:  BioPlex,STRINGDB

FAM153B

Tdark

Novelty:  4.34922003

p_int:  0.906429016

p_ni:  0.092106237

p_wrong:  0.001464747

Score:  0.239

Data Source:  BioPlex,STRINGDB

TAF1

Tchem

Family:  Kinase

Novelty:  0.00555929

Score:  0.999

Data Source:  STRINGDB

Pathways (23)

Reactome (19)

KEGG (1)

PathwayCommons (2)

WikiPathways (1)

Disease (R-HSA-1643685)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	HIV Infection	256 targets	R-HSA-162906
Reactome	HIV Life Cycle	153 targets	R-HSA-162587

Name	Explore in Pharos	Explore in Source
Disease	1105 targets	R-HSA-1643685
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
HIV Infection	256 targets	R-HSA-162906
HIV Life Cycle	153 targets	R-HSA-162587

Gene Ontology Terms (29)

Functions (9)

Components (6)

Processes (14)

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Items per page:

10

1 – 9 of 9

GO Term	Evidence	Assigned by
P-TEFb complex binding	Inferred from Direct Assay (IDA)	UniProtKB
TFIIH-class transcription factor complex binding	Inferred from Direct Assay (IDA)	UniProtKB
transcription coactivator activity	Inferred from Direct Assay (IDA)	UniProtKB
transcription regulatory region DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
histone acetyltransferase binding	Inferred from Physical Interaction (IPI)	UniProtKB
protein heterodimerization activity	Inferred from Physical Interaction (IPI)	ParkinsonsUK-UCL
thyroid hormone receptor binding	Inferred from Physical Interaction (IPI)	UniProtKB
transcription factor binding	Inferred from Physical Interaction (IPI)	UniProtKB
vitamin D receptor binding	Inferred from Physical Interaction (IPI)	UniProtKB

GWAS Traits (2)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	1	1	1		38.8
mean platelet volume	EFO_0004584	2	1	2		21.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	1		38.8
mean platelet volume	EFO_0004584	2		21.5

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UniProt Keyword Find Similar Targets

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3D-structure
Coiled coil
Complete proteome
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Transcription
Transcription regulation

GWAS Trait Find Similar Targets

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body height
mean platelet volume

MGI Phenotype Find Similar Targets

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cellular phenotype
embryo phenotype
endocrine/exocrine gland phenotype
hematopoietic system phenotype
immune system phenotype
mortality/aging

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	TATA-box binding protein associated factor 7	MGI:1346348	24074
Rat	TATA-box binding protein associated factor 7	RGD:1309935	307485
Dog	TATA-box binding protein associated factor 7	VGNC:47087	487180
Cow	TATA-box binding protein associated factor 7	VGNC:35579	509327
Pig	TATA-box binding protein associated factor 7		100523236

Species	Name	OMA	EggNOG	Inparanoid
Mouse	TATA-box binding protein associated factor 7
Rat	TATA-box binding protein associated factor 7
Dog	TATA-box binding protein associated factor 7
Cow	TATA-box binding protein associated factor 7
Pig	TATA-box binding protein associated factor 7

Publication Statistics

PubMed Score 17.17

PubMed score by year

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PubTator Score 22.15

PubTator score by year

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