Tbio TAF7 Transcription initiation factor TFIID subunit 7

Protein Summary

Description

Functions as a component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively). The intronless gene for this transcription coactivator is located between the protocadherin beta and gamma gene clusters on chromosome 5. The protein encoded by this gene is a component of the TFIID protein complex, a complex which binds to the TATA box in class II promoters and recruits RNA polymerase II and other factors. This particular subunit interacts with the largest TFIID subunit, as well as multiple transcription activators. The protein is required for transcription by promoters targeted by RNA polymerase II. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q15545
• B2RBV9
• Q13036

Gene Name

• TAF7

Ensembl ID

• ENST00000313368
• ENSP00000312709
• ENSG00000178913

Symbol

• TAF2F
• TAFII55
• TAF2F
• TAFII55

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.99
biological process	0.94
disease perturbation	0.87
histone modification site profile	0.82
molecular function	0.81

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Initiation Factor Tfiid Subunit 7

DTO Classes

Protein / Transcription Factor / Transcription Initiation Factor Tfiid Subunit 7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.36   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 165   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.36   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0